Edgardo J.C. Angtuaco MD, Presenter: Nothing to Disclose

Rudy Lee Van Hemert MD, Abstract Co-Author: Nothing to Disclose

Rohan Samant MD, Abstract Co-Author: Nothing to Disclose

Tracy L.Y. Brown MD, PhD, Abstract Co-Author: Nothing to Disclose

Manoj Kumar MD, Abstract Co-Author: Nothing to Disclose

James E. McDonald MD, Abstract Co-Author: Institutional research collaboration, Mirada Medical Ltd

Twyla Brianne Bartel DO, MBA, Abstract Co-Author: Nothing to Disclose

Sanjaya Viswamitra MD, Abstract Co-Author: Nothing to Disclose

To discuss the technique of whole body diffusion weighted imaging (DWIBS) and its application in the surveillance of patients with multiple myeloma

1. Overview of DWIBS in comparison to standard MR techniques (T1 and STIR) and PET/CT 2. Case illustrations of patients with multiple myeloma at different stages of the disease using DWIBS, standard MRI and PET/CT 3. Demonstration of cases where DWIBS showed distinct advantage compared to the other techniques in detecting multiple myeloma lesions 4. Demonstration of cases where standard MRI or PET/CT were better than DWIBS in detecting myeloma lesions 5. Illustrate cases where interpretation of DWIBS are affected by prior therapy such as GCSF, radiation and surgery 6. Summarize our experience in 80 patients with newly diagnosed myeloma regarding initial assessment and followup of these patients

DWIBS provides a more rapid assessment of patients with multiple myeloma and provides good correlation with CT/PET and standard MR techniques.  DWIBS provides total body evaluation comparable to PET/CT without added radiation exposure.  Serial DWIBS can be performed to assess response of demonstrated disease and demonstrate presence of relapse.  Knowledge of prior therapy such as GCSF, radiation and surgery will affect interpretation of DWIBS studies.

Angtuaco, E, Van Hemert, R, Samant, R, Brown, T, Kumar, M, McDonald, J, Bartel, T, Viswamitra, S, Whole Body Diffusion-weighted MR Imaging (DWIBS) in Multiple Myeloma.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12035629.html