Stephen L. Rose MD, Presenter: Consultant, Hologic, Inc

Mary F. Ice MD, Abstract Co-Author: Nothing to Disclose

Amy Sullivan Nordmann MD, Abstract Co-Author: Nothing to Disclose

Russ C. Sexton DO, Abstract Co-Author: Nothing to Disclose

Rui Song MD, Abstract Co-Author: Nothing to Disclose

To compare recall rates using FFDM plus Tomosynthesis to those using FFDM alone in a screening population.

A retrospective review of 10,000 consecutive asymptomatic patients who underwent routine screening mammography with FFDM+Tomosynthesis (Selenia® Dimensions® Breast Tomosynthesis; Hologic, Inc) is ongoing. A planned interim analysis of the first 4000 patients was conducted to compare recall rates, review cancer detection and confirm sample size. Thirteen radiologists reviewed images from 4028 patients. The interpretation of the FFDM+Tomosynthesis was completed as part of the standard clinical evaluation, and used for patient management. Lesion type and follow-up were recorded for all recalled cases. A second radiologist, blinded to the initial results, read only the FFDM mammogram. Priors (if available) and clinical history were provided for all interpretations. The recall decision was recorded for each case. McNemar’s test was used to compare overall recall rates between reading methods. To correct for differences in recall rates between the FFDM and FFDM+Tomosynthesis readers a generalized mixed model was used with corrections based on each individual’s baseline FFDM recall rate.  

For the evaluation of FFDM+Tomosynthesis, 232 cases were recalled (recall rate 5.76%, 232/4028) while the FFDM interpretations identified 355 recall cases (recall rate 8.81%, 355/4028). This represents a 35% relative reduction in recall rates for FFDM+Tomosynthesis compared to FFDM alone. This reduction is significant by McNemar’s test (p<0.0001). This relative difference was unchanged after correction for readers’ baseline recall rates. Of the 25 cancer cases recalled using FFDM + Tomosynthesis, 19 were identified as recall cases using FFDM alone.

The combination of FFDM and Tomosynthesis for screening asymptomatic patients markedly reduced recall rates compared to the use of FFDM alone.

Adding tomosynthesis to FFDM reduced recall rates in a routine screening population by approximately 35%.

Rose, S, Ice, M, Nordmann, A, Sexton, R, Song, R, A Comparison of Recall Rates between Full Field Digital Mammography (FFDM) and Full Field Digital Mammography Plus Tomosynthesis in a Community Setting.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12033875.html