Claudia Cotes MD, Presenter: Nothing to Disclose

Roy Riascos MD, Abstract Co-Author: Nothing to Disclose

Sandra Parada MD, Abstract Co-Author: Nothing to Disclose

Reza Hakimelahi MD, Abstract Co-Author: Nothing to Disclose

Maria Claudia Caldas Vasquez, Abstract Co-Author: Nothing to Disclose

Leonard Edward Swischuk MD, Abstract Co-Author: Nothing to Disclose

Review the process of anterior diverticulation of the brain with 3D dynamic diagrams. Show the continuum of the spectrum of how holoprosencephaly occurs. Explain the genetic anomalies associated with holoprosencephaly. Explain the types of septo-optic dysplasia.

Embryonic diverticulation. Differentiation of the prosencephalon. Abnormalities in ventral induction of the prosencephalon. Holoprosencephaly: Alobar, Semilobar, Lobar, and Midline interhemispheric variant. Genes positively implicated in holoprosencephaly. The face predicts the brain. Septo-optic dysplasias, phenotypes.

Holoprosencephaly is a complex malformation of the forebrain that results from failure of the developing brain to cleave laterally into two distinct hemispheres. There are different types of holoprosencephaly with varying grades of severity, with all of them having in common the absence of the septum pellicidum. Understanding the development of the septum pellicidum and fornix is essential in the recognition of midline brain defects.

Cotes, C, Riascos, R, Parada, S, Hakimelahi, R, Caldas Vasquez, M, Swischuk, L, Interactive Explanation of Holoprosencephalic Developmental Anomalies  .  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12032901.html