Ahmet Veysel Polat MD, Presenter: Nothing to Disclose

Vedat Eyiisler, Abstract Co-Author: Nothing to Disclose

Cetin Celenk, Abstract Co-Author: Nothing to Disclose

Leman Tomak, Abstract Co-Author: Nothing to Disclose

The role of diffusion-weighted imaging (DWI) in differential diagnosis of pulmonary malignant tumours and solid benign lesions by using mean apparent diffusion coefficient (ADC) values was evaluated prospectively in this study.

Forty four patients with pulmonary lesions were included. Diffusion weighted images in the axial plane were obtained by using a 1.5 Tesla MRI device, parallel imaging, single shot echo-planar spin echo T2 weighted sequences on 3 axes, and diffusion sensitive gradients with 3 different b values (0, 500, 1000 s/mm2). ADC maps which were obtained with high b values, despite without the knowledge of histopathological diagnoses. Then the patients were divided into benign and malignant groups according to their histopathological diagnoses. Sensitivity, specificity and other table statistics were used to evaluate the data. Optimal cut off value of ADC in differentiation of the lesions as benign or malignant, were estimated by using ROC analysis.

The lesions were malignant in thirty four (77.3%), and were benign in ten (22.7%) of the patients. There were statistically significant differences (p<0.05) between ADC values of benign and malignant lesions. The average of the ADC values were found 1.09±0.05x10-3 mm2/sn. ROC analysis is utilized to find the optimal cut off value of ADC of the patients. The optimal cut off value of ADC was found 1.20x10-3mm2/sn with 85 % sensitivity and 70 % specificity. AUC value with the estimated data was found 0.836 and this value was statistically significant (p<0.001).

Diffusion-weighted MRI with quantitative ADC measurements can be useful in the differentiation of benign and malignant pulmonary lesions. Thus, we thought, the need of interventional techniques could be decreased by using DWI, especially in the cases clinically suspected as malignant.

Diffusion-weighted MRI with quantitative ADC measurements can be useful in the differentiation of benign and malignant pulmonary lesions.

Polat, A, Eyiisler, V, Celenk, C, Tomak, L, Diagnostic Value of Apparent Diffusion Coefficients in the Differentiation of Benign and Malignant Pulmonary Lesions.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12029661.html