Bi Jing Zhou, Presenter: Nothing to Disclose

Zhen Wei Yao MD, Abstract Co-Author: Nothing to Disclose

Huijin He MD, PhD, Abstract Co-Author: Nothing to Disclose

Xiaoyuan Feng MD, Abstract Co-Author: Nothing to Disclose

Relative cerebral blood volume (rCBV) and vascular permeability (K-trans) are usually performed in assessment of glioma microvasculature. But which parameter can predict more accurate position for MR-guided biopsy is still a debate now. In this study, we researched the associations between rCBV and K-trans to estimate whether the regions of their maximal abnormality are in the same position.

Sixty-three patients with primary gliomas underwent conventional and DSC MR imaging. Data were analyzed using MIStar version 3.2. The regions of maximal abnormality were respectively detected on rCBV and K-trans color maps, and also compared to contrast-enhanced MR images. The maximal K-trans values were compared with the K-trans measured on K-trans color maps corresponding to maximal rCBV region of the same slice. T-test was used for statistical analysis.

The maximal rCBV region from the rCBV map did not correspond to the region of maximal permeability suggested by the K-trans map in about 75% gliomas of our study. The K-trans from the region of maximal rCBV were statistically different from maximal K-trans (P<0.01). Mismatch of rCBV and vascular permeability could be classified as following: 1. The maximal rCBV region was in the central part of the tumor but the maximal K-trans region was near the boundary (18/63); 2. The maximal rCBV region was near the boundary but the maximal K-trans region was in the central part (9/63); 3. Both the maximal rCBV and maximal K-trans regions were in the contrast-enhanced part of the tumor, but were not in the same position (20/63).

Mismatch of rCBV and permeability derived from DSC-enhanced perfusion MR imaging, which appears three types, is a common phenomenon in gliomas. Further research is needed to determine which parameter can predict more accurate position for biopsy.

MR perfusion can demonstrate tumor angiogenesis and is recommended as part of a MR study prior to brain tumor removal.

Zhou, B, Yao, Z, He, H, Feng, X, Mismatch of Cerebral Blood Volume and Vascular Permeability Derived from 3T Dynamic Susceptibility-weighted Contrast Enhanced Perfusion MRI in Glioma.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12029466.html