Diagnosis and Prognostic Profiles for the Genotype/Phenotype Subgroups of Hepatocellular Adenomas Using Contrast-Enhanced MRI with Histopathological Correlation

LL-GIE3073-SUA

Diagnosis and Prognostic Profiles for the Genotype/Phenotype Subgroups of Hepatocellular Adenomas Using Contrast-Enhanced MRI with Histopathological Correlation

Education Exhibits

Presented on November 25, 2012
Presented as part of LL-GIE-SU: Gastrointestinal Lunch Hour CME Exhibits

Ahmed Ba-Ssalamah MD, Presenter: Nothing to Disclose

Nina Bastati MD, Abstract Co-Author: Nothing to Disclose

Diana Sorina Feier MD, Abstract Co-Author: Nothing to Disclose

Christian J. Herold MD, Abstract Co-Author: Nothing to Disclose

Filipe Caseiro Alves MD, Abstract Co-Author: Nothing to Disclose

To demonstrate the diagnostic value of contrast-enhanced MRI with different contrast agents to establish an accurate diagnosis and sub-classification of hepatocellular adenomas (HCAs).

Although HCA is classified as a benign liver lesion, clinically, it is considered a borderline tumor due to the risk of hemorrhage, rupture, and even malignant transformation. Therefore, the management of this lesion varies, and can include invasive biopsy, long term follow up, surgical resection or even radiofrequeny ablation, based on the size, histological subtype, and clinical presentation. Recently, HCAs have been divided into genotype/phenotype subgroups, including (1) hepatocyte nuclear factor 1α(HNF-1α)–inactivated, (2) β-catenin–activated, (3) inflammatory, and (4) a unclassified or mixed type. These genotype/phenotype subgroups are associated with different prognostic profiles. The recent literature has reported a close correlation between pathological classification of HCAs and imaging features on magnetic resonance imaging (MRI).

In this educational exhibition, we demonstrate the correlation of the MRI features of hepatocellular adenomas and their genotype/phenotype subgroups. We highlight the role of contrast-enhanced MRI as a predictive tool to estimate the malignant potential of the different subgroups of HCAs and guide the therapy.

Ba-Ssalamah, A, Bastati, N, Feier, D, Herold, C, Caseiro Alves, F, Diagnosis and Prognostic Profiles for the Genotype/Phenotype Subgroups of Hepatocellular Adenomas Using Contrast-Enhanced MRI with Histopathological Correlation. Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12028238.html