Rachel Anne Lagos DO, Presenter: Nothing to Disclose

Gary Marano MD, Abstract Co-Author: Nothing to Disclose

Jame Abraham MD, Abstract Co-Author: Nothing to Disclose

Marc Haut PHD, Abstract Co-Author: Nothing to Disclose

Sara Kurian MS, Abstract Co-Author: Nothing to Disclose

This research clinically correlates patient history, neurologic examination, and chemotherapy regimen with the 18F FDG PET-CT imaging for 128 patients diagnosed with breast cancer. This data is reviewed at the time of staging and six-month re-staging image acquisitions in patients who received interim chemotherapy. The clinical context of statistically significant image findings is established.

One hundred twenty-eight breast cancer patients' staging and re-staging 18F FDG PET-CT Brain examinations are retrospectively reviewed. NeuroMim neuroradiology analysis software calculates the brain metabolism within 63 brain regions compared to a standard metabolism model for each diagnostic image set. Variance of these Z-score values is calculated for each patient prior to and post chemotherapy. The statistical significance of the changes in brain metabolism is calculated within the total patient population. These results are clinically correlated with documented patient history, neurologic examinations, and chemotherapy regimens. The clinical presentation of chemobrain phenomenon and the statistically significant regional decreases in brain metabolism are correlated.

In women treated for breast cancer, 18F FDG PET-CT demonstrates statistically significant decreases in regional brain metabolism. The metabolic change correlates to chemotherapy regimen, neurological examination and symptoms of chemobrain phenomenon.

Correlation between clinical and imaging data evaluates the role of 18F FDG PET-CT as a diagnostic tool for chemobrain phenomenon.

This research provides statistically significant data evaluating the use of 18F FDG PET-CT as a diagnostic tool for chemobrain phenomenon, facilitating clinical diagnosis and treatment.

Lagos, R, Marano, G, Abraham, J, Haut, M, Kurian, S, Towards Diagnostic Imaging of ChemoBrain Phenomenon.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12025812.html