Martin W. Huellner, Presenter: Research Grant, Siemens AG Research Grant, Bayer AG

Martin Banyai, Abstract Co-Author: Nothing to Disclose

Klaus Strobel MD, Abstract Co-Author: Nothing to Disclose

Patrick Veit-Haibach, Abstract Co-Author: Research Grant, Bayer AG Research Grant, Siemens AG

1. To assess the change of CT-perfusion (CTP) parameters (blood flow (BF), blood volume (BV), mean transit time (MTT)) after interventional revascularisation in patients with symptomatic peripheral arterial disease. 2. To correlate the change of CTP parameters with pre-interventional angiographic parameters.

Thirty patients (median age 72 years, range 48 to 87 years) with peripheral arterial disease were prospectively included. All patients were referred for interventional revascularisation of an occlusion or a high-grade stenosis. A CTP scan of the calf was performed before and after intervention (60ml of contrast medium at 5ml/s flow rate, delay 15s, tube voltage 100kV, tube current 100mAs, scan length 28.2cm, scan time 60s, rotation time 1s, reconstructed slice thickness 10mm). BF, BV, and MTT of muscle tissue were calculated. A t-test was performed to analyse the variance between CTP parameters pre/post intervention. The delta (Δ) pre/post was correlated with angiographic parameters, degree of collateralization (qualitatively), and length of stenosis or occlusion (quantitatively) by Pearson's correlation coefficient.

Mean pre-interventional BF, BV and MTT was 7.4 mL/100mL tissue * min-1, 0.7 mL/100mL tissue, and 7.4 seconds. Mean post-interventional BF, BV and MTT was 11.0 mL/100mL tissue * min-1, 1.3 mL/100mL tissue, and 7.6 seconds. The change of BF and BV was statistically significant (p-value 0.011, 0.015, respectively). Mean length of occlusion was 8.6cm (14 short (<5cm), 8 medium (5-10cm), 8 long segment lesions (>10cm)). Degree of collateralization was good in 10, medium in 15, and poor in 6 patients. A strong correlation was found between ΔBF and lesion length (0.67), a medium correlation between ΔBV and lesion length (0.45). No correlation was found between degree of collateralization and CTP parameters.

CT-perfusion parameters increase after therapeutic vascular intervention. ΔCTP parameters showed moderate to strong correlations with lesion length, but not with degree of collateralization. CTP might serve as a semiquantitative, non-operator dependent and non-invasive method to assess the success of revascularization in peripheral arterial disease.

CT-perfusion might serve as a non-operator dependent and non-invasive method to assess the success of revascularization.

Huellner, M, Banyai, M, Strobel, K, Veit-Haibach, P, CT-perfusion in Patients with Symptomatic Peripheral Arterial Disease (PAD): Change of Perfusion Parameters after Interventional Revascularisation and Correlation with Pre-interventional Angiographic Parameters  .  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12024717.html