Yong-An Chung MD, PhD, Presenter: Nothing to Disclose

In-Uk Song, Abstract Co-Author: Nothing to Disclose

Kijun Kim, Abstract Co-Author: Nothing to Disclose

Sang Hoon Lee, Abstract Co-Author: Nothing to Disclose

Statistical parametric mapping was performed to investigate differences in regional cerebral blood flow (rCBF) between patients with idiopathic Parkinson’s disease (IPD), patients with multiple system atrophy (MSA), and healthy volunteers.

Tc-99m HMPAO SPECT was performed on 23 IPD patients (10 men, 13 women; age, 57-80 years), 9 MSA patients (4 men, 5 women; age, 60-83 years), and 12 age- and sex-matched healthy volunteers (5 men, 7 women; age, 56-81 years).

Significant hypoperfusion was observed in IPD compared with healthy subjects in a symmetric subcortical-cortical network including the basal ganglia, thalami, prefrontal and lateral frontal cortex, and parietal cortex (voxel size: 50, corrected P < 0.001). For MSA, only symmetric hypoperfusion was seen in the both prefrontal cortices with respect to healthy subjects and to IPD (voxel size: 50, corrected P < 0.001).

Tc-99m HMPAO perfusion SPECT shows detailed differences between IPD and MSA, which may be of use in the differentiation of both disease entities.

The rCBF pattern for PD corresponds to a fairly frontal-subcortical network.

Chung, Y, Song, I, Kim, K, Lee, S, Difference of Regional Cerebral Blood Flow in Idiopathic Parkinson’s Disease and Multiple System Atrophy.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12020461.html