Huaibing Cheng, Presenter: Nothing to Disclose

Shihua Zhao MD, Abstract Co-Author: Nothing to Disclose

Shiliang L Jiang, Abstract Co-Author: Nothing to Disclose

Minjie Lu, Abstract Co-Author: Nothing to Disclose

Chaowu Yan MD, Abstract Co-Author: Nothing to Disclose

Yan Zhang, Abstract Co-Author: Nothing to Disclose

Qiong Liu, Abstract Co-Author: Nothing to Disclose

Ning Ma, Abstract Co-Author: Nothing to Disclose

Gang Yin BS, Abstract Co-Author: Nothing to Disclose

To investigate risk factors for life-threatening ventricular arrhythmia in arrhythmogenic right ventricular cardiomyopathy (ARVC) by cardiovascular magnetic resonance imaging (CMR).

Clinical markers and CMR parameters were compared between 27 patients with sustained ventricular tachycardia or ventricular fibrillation (group 1) and remaining 36 patients (group 2). All CMR datasets were analyzed using the 17-segment model.

There were significantly differences between both groups in terms of familial history of ARVC or sudden death (40.7% vs 13.9%, P = 0.015), the accordion sign (85.2% vs 61.1%, P = 0.036), left ventricular involvement (74.1% vs 47.2%, P = 0.032), number of segments with intramyocardial fat infiltration (5.4±3.8 vs 3.4±2.2, P = 0.020), number of segments with myocardial fibrosis (5.1±4.0 vs 2.2±2.1, P = 0.001). A binary logistic regression model showed that familial history of ARVC or sudden death (odds ratio [OR] = 4.536, 95% CI 1.135-18.125; P = 0.032) and number of segments with myocardial fibrosis (OR = 1.410, 95% CI 1.119-1.776; P = 0.004) were independent predictors for life-threatening ventricular arrhythmia in ARVC.

Familial history of ARVC or sudden death and number of segments with myocardial fibrosis were independent predictors for life-threatening ventricular arrhythmia in ARVC.

The early and accurate detection of CMR is useful to save lives of patients with ARVC.

Cheng, H, Zhao, S, Jiang, S, Lu, M, Yan, C, Zhang, Y, Liu, Q, Ma, N, Yin, G, Noninvasive Risk Factors Predisposing to Life-threatening Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy Using Magnetic Resonance Imaging.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11034615.html