Rika Fukui, Presenter: Nothing to Disclose

Haruhiko Machida MD, Abstract Co-Author: Nothing to Disclose

Isao Tanaka, Abstract Co-Author: Nothing to Disclose

Kazufumi Suzuki MD, Abstract Co-Author: Nothing to Disclose

Cheng Zhou MD, Abstract Co-Author: Nothing to Disclose

Eiko Ueno MD, Abstract Co-Author: Nothing to Disclose

Munekuni Sato, Abstract Co-Author: CEO, FUYO Corporation

Yun Shen PhD, Abstract Co-Author: Employee, General Electric Company Researcher, General Electric Company

To investigate the feasibility of fast switching of 80 and 140 kVp in each view (fast kVp-switching) for accurately measuring vessel density with single-source dual-energy CT (ssDECT) using a phantom simulating contrast-enhanced vessels of different densities and diameters undergoing respiratory motion.

In Experiment A, we placed a cylindrical moving phantom at isocenter with 8 cylindrical tubes of 18-mm diameter filled with 0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 30.0, and 50.0 mg/mL of iodine contrast medium symmetrically in the phantom’s periphery, all parallel to the z-axis. In Experiment B, we placed tubes of 4-, 6-, 8-, 10-, 12-, 14-, 16-, and 18-mm diameter filled with 12.0 mg/mL of contrast medium as in Experiment A. By fast kVp switching with a 64-detector ssDECT scanner (Discovery CT750 HD, GE), we scanned the phantom moving perpendicularly with amplitudes of 0, 2, and 8 mm at 5 and 10 bpm. With every phantom motion, we measured iodine density in each tube using regions of interest of half the area of the tube cross-section on a reconstructed iodine-density short-axis image and used one-way ANOVA test to compare density between the stationary and moving states of the phantom under the same condition with different iodine densities (A) and tube diameters (B).  

(A) With different iodine densities (0.5-50.0 mg/mL), measured iodine densities at the stationary state were 0.58 ± 0.02, 1.08 ± 0.03, 2.20 ± 0.01, 5.46 ± 0.06, 11.45 ± 0.05, 21.61 ± 0.08, 32.14 ± 0.07, and 53.02 ± 0.17 mg/mL and at the moving state, 0.52 ± 0.10, 1.06 ± 0.05, 2.09 ± 0.04, 5.33 ± 0.08, 11.23 ± 0.15, 21.19 ± 0.14, 31.66 ± 0.21, and 52.33 ± 0.42 mg/mL. (B) With different tube diameters, the measured densities at the stationary state were 11.03 ± 0.43, 11.99 ± 0.15, 12.30 ± 0.07, 12.34 ± 0.05, 12.34 ± 0.03, 12.41 ± 0.05, 12.47 ± 0.05, and 12.56 ± 0.05 mg/mL, and at the moving state, 10.57 ± 0.11, 11.91 ± 0.07, 12.30 ± 0.04, 12.34 ± 0.05, 12.36 ± 0.03, 12.45 ± 0.04, 12.51 ± 0.06, and 12.53 ± 0.05 mg/mL. Measurements did not differ significantly between the 2 states in each experiment (P > 0.05).

Use of fast kVp-switching with ssDECT permits accurate measurement of the density of contrast-enhanced vessels even with respiratory motion.

Use of fast kVp-switching with single-source dual-energy CT may be clinically useful for accurately measuring the density of various materials, even in the presence of respiratory motion.

Fukui, R, Machida, H, Tanaka, I, Suzuki, K, Zhou, C, Ueno, E, Sato, M, Shen, Y, Feasibility of Fast kVp-switching with Single-Source Dual-Energy CT for Accurately Measuring Vessel Density in the Presence of Respiratory Motion: Phantom Experiment Using Iodine.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11034576.html Accessed March 15, 2025