Tatiana Peysakhovich, Abstract Co-Author: Nothing to Disclose

Arie Biterman, Abstract Co-Author: Nothing to Disclose

Eithan Shiloni, Abstract Co-Author: Nothing to Disclose

Mariana Steiner, Abstract Co-Author: Nothing to Disclose

Tamar Gaspar MD, Abstract Co-Author: Nothing to Disclose

Judith Goldman MD, Presenter: Nothing to Disclose

Intaraoperative breast irradiation is becoming a new treatment alternative to the standard adjuvant whole breast irradiation in low risk early breast cancer patient. A single dose of 20 Gy administrated to the tumor bed may cause significant post surgery changes in breast tissues. These changes could complicate the breast post radiotherapy breast imaging and lead to additive diagnostic procedures.

We analyzed the first consecutive 100 patients treated who underwent at least three mammography studies during the follow-up of period (approximately 6, 12, and 18 months of procedure). We assessed mammography changes, and ultrasound findings, fluid aspirations and tru-cut biopsies if performed.

In 19% patients the first mammography detected pathological findings: 12% seroma, 6% microcalcification and 1% suspected lesions. In the second mammography , findings were reported in 14% patients: 7% seroma, 6% microcalcification and 1% suspected tumor. Third mammography detected 11 findings : 5% seroma, 4% microcalcificatains, 1% severe fibrosis and 1% suspected tumor. In 29% of patients ultrasound was performed due to palpatory and/or mammographic findings. In 58 of 86 ultrasound changes (67%) showed the abnormal findings. The changes were mostly post operative changes and seromas. 4 images (7%) detected suspected lesions. Ultrasound guided fluid aspiration was performed in 8% of patients, all cytological examinations were normal. Imaging guided tru-cut biopsy was performed in 9% of patients due to imaging findings, only 2 malignant tumors were detected.

The changes in the breast tissue due to single dose , intraoperative radiotherapy cause more mammography findings which lead to much more frequent use of additional investigations. The addition of ultrasound may reduce the need of invasive diagnostic tests.

To identify the mammography changes and ultrasound findings following intaraoperative breast irradiation

Peysakhovich, T, Biterman, A, Shiloni, E, Steiner, M, Gaspar, T, Goldman, J, Imaging Evaluation of Breast after Intraoperative Radiotherapy (IORT) in Early Breast Cancer Patients.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11034404.html