Toshihiko Sugiura, Presenter: Nothing to Disclose

Nobuhiro Tanabe, Abstract Co-Author: Nothing to Disclose

Koichiro Tatsumi, Abstract Co-Author: Nothing to Disclose

Nobusada Funabashi MD, PhD, Abstract Co-Author: Nothing to Disclose

We retrospectively determined whether the curvature of the interventricular septum measured by ECG-gated conventional scanning with 320-slice computed tomography (CT) was influenced by pulmonary artery (PA) pressure in subjects with chronic thromboembolic pulmonary hypertension (CTEPH).

Subjects (n=40, 60±11 yrs, 13 male) with proven CTEPH underwent right heart catheterization (RHC) and double volume retrospective ECG-gated enhanced conventional scanning using 320-slice CT (Aquilion ONE, Toshiba Medical) to obtain images of the whole heart, coronary arteries and pulmonary arteries. CT images were reconstructed every 5% from 0-95% of the R-R interval, and a series of short-axis images of the heart at the level of papillary muscle of left ventricle was acquired using double oblique multiplanar reformation (Zio Station). We compared septal bowing expressed as end-systolic curvature (reciprocal of radius [/cm], a leftward curvature was denoted as a negative value) with both systolic and mean pulmonary artery pressures (sPAP, mPAP).

sPAP and mPAP from RHC were 71.9±21.1 mmHg and 41.2±11.9 mmHg, respectively. The correlation coefficients of septal curvature with sPAP and mPAP were -0.71 (P<0.001) and -0.79 (P<0.001), respectively.

Septal curvature based on ECG-gated 320-slice CT can be used to accurately estimate sPAP and mPAP in subjects with CTEPH. This imaging modality can be used to detect thrombi in the pulmonary arteries as well as to evaluate hemodynamics in CTEPH subjects.

Septal curvature based on ECG-gated 320-slice CT can be used to accurately estimate sPAP and mPAP in subjects with CTEPH.

Sugiura, T, Tanabe, N, Tatsumi, K, Funabashi, N, Estimation of Pulmonary Arterial Pressure in Chronic Thromboembolic Pulmonary Hypertension, Based on Interventricular Septal Configuration Obtained by Electrocardiogram-gated 320-Slice CT.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11020167.html