Sun Jun An, Presenter: Nothing to Disclose

Tae Hee Kim MD, Abstract Co-Author: Nothing to Disclose

Taehee Kim, Abstract Co-Author: Nothing to Disclose

Doo Kyung Kang MD, Abstract Co-Author: Nothing to Disclose

Eun Young Kim, Abstract Co-Author: Nothing to Disclose

To investigate the utility of MRI and PET-CT in the prediction of pathologic response to neoadjuvant chemotherapy using Miller-Payne grading system in patients with breast cancer.

Fifty-four consecutive patients with pathologically proven breast cancer who underwent neoadjuvant chemotherapy followed by surgery, were retrospectively enrolled. The percentage diameter reduction rate (MRI) and SUV reduction rate (PET/CT) for both the primary breast mass and largest axillary LN were calculated and correlated with the Miler-Payne grading system. Patients with Miller-Payne grade 1 or 2 were classified into the non-responder group and patients with 3,4 and 5 were responder group.

Among the four parameters, the correlation factor was highest in the diameter reduction rate of primary breast mass (ρ = 0.643, P = 0.000) followed by SUV reduction rate of the primary breast mass (ρ = 0.561, P = 0.000), SUV reduction rate of the index node (ρ = 0.430, P = 0.007) and diameter reduction rate of the index node (ρ = 0.349, P = 0.013). To differentiate between responders and non-responders, an ROC analysis was performed at different cutoff levels for the % reduction rate. The area under the ROC curve (Az) value was largest in the % SUV reduction rate of primary breast cancers (Az = 0.875), followed by the % diameter decrease of the primary cancrs (Az = 0.842), and % SUV reduction rate of the index node (Az = 0.745).

Measurement of the diameter reduction rate and SUV reduction rate of the primary breast mass may be the accurate tool in the prediction of pathologic response after neoadjuvant chemotherapy based on Miller-Payne grading system in breast cancer patients.

MRI and PET-CT evaluation of primary breast cancer using Miller-Payne grading system is accurate method for prediction of pathologic response after neoadjuvant chemotherapy.  

An, S, Kim, T, Kim, T, Kang, D, Kim, E, Utility of MRI and PET-CT for Evaluating Pathologic Response to Neoadjuvant Chemotherapy Based on Miller-Payne Grading System in Breast Cancer Patients.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11016338.html