RSNA 2011 

Abstract Archives of the RSNA, 2011


LL-BRS-TH2A

Evaluation of HER-2 in Fine-Needle Aspirates at Preoperative US-guided Axillary Lymph Node Aspiration in Patient with Breast Cancer: Comparison with Positivity of Metastasis and with HER-2 in Tissue of Primary Breast Cancer

Scientific Informal (Poster) Presentations

Presented on December 1, 2011
Presented as part of LL-BRS-TH: Breast Imaging

Participants

Min Jung Kim MD, Presenter: Nothing to Disclose

PURPOSE

to compare the HER-2 level in fine-needle aspirates (FNA) of US-guided axillary lymph node aspiration and that in tissue of primary breast cancer and to assess the usefulness of HER-2 from aspirates of axillary lymph node in determination of lymph node metastasis or prediction of tumor characterization.

METHOD AND MATERIALS

we included 178 patients with stage 0-3 breast cancer. The FNA HER-2 level from axillary lymph node was measured by chemiluninescence immune (ADIVIA Centaur® system) during the preoperative period. The level of HER-2 in all of the breast cancer tissue samples was determined by immunohistochemistry (IHC), and samples with an IHC grade +2 or +3 were subject to fluorescence in situ (FISH). The HER-2 level in FNA of lymph node was correlated with metastasis of lymph node and compared with the HER-2 level in the primary breast cancer based on IHC and FISH.

RESULTS

the mean/median HER-2 level in FNA was 0.0/0.0ng/mL in non-metastatic lymph node and 6.2/0.0ng/mL in metastatic lymph node. Of metastatic lymph nodes, the mean/median FNA HER-2 level in lymph node with 0 or +1 IHC HER-2 in tissue of primary breast cancer was 0.0/0.0ng/ mL and those with +3 was 18.6/3.9ng/mL (p=0.0003). The HER-2 level in FNA of metastatic lymph node was significantly correlated with the IHC grade of HER- level in tissue of primary breast cancer (r=0.2863, p=0.0004). Among cases in which FISH was undertaken, primary breast cancer with FISH positivity showed higher HER-2 level in FNA of metastatic lymph node than the cases with FISH negativity (median, 4.05ng/mL vs 0.0ng/mL; p<0.0001).

CONCLUSION

Evaluation of HER-2 level in FNA at preoperative US-guided axillary lymph node aspiration in patient with breast cancer could be helpful for the preoperative diagnosis of axillary lymph node metastasis and prediction of HER-2 status of primary breast cancer.

CLINICAL RELEVANCE/APPLICATION

If HER-2 is elevated in FNA at preoperative US-guided axillary lymh node ;aspiration, we could predict the metastasis of corresponding lymph node; and; HER-2 positivity in primary breast cancer.

Cite This Abstract

Kim, M, Evaluation of HER-2 in Fine-Needle Aspirates at Preoperative US-guided Axillary Lymph Node Aspiration in Patient with Breast Cancer: Comparison with Positivity of Metastasis and with HER-2 in Tissue of Primary Breast Cancer.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11014945.html