Anbok Lee, Presenter: Nothing to Disclose

Jihyun Lee, Abstract Co-Author: Nothing to Disclose

Jina Chang, Abstract Co-Author: Nothing to Disclose

Woosung Lim, Abstract Co-Author: Nothing to Disclose

Bom Sahn Kim, Abstract Co-Author: Nothing to Disclose

Byung-In Moon, Abstract Co-Author: Nothing to Disclose

The purpose of our study was to compare the performance results of MMG, US, and BSGI for cancer detection according to breast density.  

Between Feb. 2009 and Dec. 2010, 662 patients who underwent BSGI, US, and MMG were enrolled, retrospectively. All results of each examination were analyzed according to breast density and compared with pathologic results. For BSGI interpretation, no uptake or diffuse non-specific uptake were considered as a negative finding and mild or enhanced focal uptake were considered as a positive finding. On the other hand, MMG and breast US were evaluated by the BIRADS system. Category 4, 5 were considered as a positive finding. Category 6 lesions were excluded from this study.

The mean age of the 662 patients with 665 lesions was 49.6 ± 10.6 years (age raging from 26 to 88 years). Among these, 193 lesions were malignancy, and the other lesions were benign. The overall sensitivity and specificity of BSGI were 95.3% (confidence interval (CI):91.3%-97.9%), and 87.9% (CI: 84.6%-90.7%). Those of MMG were 75.1% (CI: 68.4%-81.1%), and 96.8% (CI: 94.8%-98.2%). In the case of US, the overall sensitivity and specificity were 99.5% (CI: 97.15%-100.0%), and 85.6% (CI: 82.1%-88.64%), respectively. In the dense breasts (breast density ≥ 50%), sensitivities of BSGI, MMG, and breast US were 95.1% (CI: 89.7%-98.2%), 70.7% (CI: 61.9%-78.6%), and 99.2% (CI: 99.2%-100.0%). While in the fatty or fibroglandular breasts (breast density < 50%), those sensitivities were 95.7% (CI: 88.0%-99.1%), 82.9% (CI: 72.0%-90.8%), and 100% (CI: 94.9%-100.0%), respectively. Additionally, the sensitivity and specificity of BSGI for axillary lymph node (LN) status were 51.7 % (CI: 38.2%-65.1%) and 87.2 % (CI: 80.1%-92.5%).  

Generally, the sensitivity of BSGI is superior to that of MMG, and specificity of BSGI is superior to that of US. And the result of BSGI seems to be less affected by breast density. BSGI is a good imaging modality with high sensitivity for breast cancer detection for Korean women, who have dense breast tissue. However, the more lots of cases might be needed to evaluate this problem.

BSGI is a good diagnostic modality for breast cancer detection not only for the fatty or fibroglandular breast tissue but also for the dense breast tsuue.

Lee, A, Lee, J, Chang, J, Lim, W, Kim, B, Moon, B, The Efficacy of Breast-specific Gamma Imaging with 99mTc-Sestamibi in the Diagnosis of Breast Cancer according to Breast Density for Korean Women.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11013862.html