Francesca Maccioni MD, Abstract Co-Author: Nothing to Disclose

Najwa Alansari, Presenter: Nothing to Disclose

Fabrizio Mazzamurro MD, Abstract Co-Author: Nothing to Disclose

Flavio Barchetti, Abstract Co-Author: Nothing to Disclose

Ilaria Staltari MD, Abstract Co-Author: Nothing to Disclose

Mario Marini MD, Abstract Co-Author: Nothing to Disclose

Peutz-Jeghers syndrome (PJS) is a familial polyposis syndrome characterized by multiple hamartomatous polyps throughout the gastrointestinal tract. It is usually studied by invasive or moderately invasive techniques, such as capsule endoscopy, pushed enteroscopy, conventional or MR-enteroclysis. The aim of our study was to determine the diagnostic value of a specific MR Enterography (MRE) technique in the detection of small bowel polyps in PJ patients, based on the acquisition of fluid sensitive sequences both in supine and prone position, after oral administration of a biphasic contrast agent.

MRE examinations were performed in 10 PJS patients who subsequently underwent capsule endoscopy pushed-double-balloon enteroscopy and/or laparoscopic-endoscopy and/or surgery, within 3 months. Approximately two liters of polietilenglicole was orally administered before the examination. True-FISP and HASTE sequences were acquired in supine and prone position; 3D-VIBE-Gd-enhanced sequences were acquired in prone position only.

Concordance between MRE and endoscopy was 74 % for polyps <15 mm, 95% for polyps >15 mm. In supine and prone position only, concordance with endoscopy for polyps <15 mm was 62% and 68% respectively. In the detection of smaller polyps the difference between supine position only and supine plus prone position was statistically significant (p < 0.05).

MRE in prone and supine position was accurate in the detection of PJS polyps, with 95% concordance with enteroscopy for larger and more risky polyps. MRE offers a promising alternative to capsule endoscopy, suggesting the possibility of an effective yearly surveillance in PJ patients.

MRE, showing high diagnostic accuracy in the detection of PJS polyps, offers a promising alternative to capsule endoscopy, suggesting the possibility of an effective yearly surveillance in PJ patients

Maccioni, F, Alansari, N, Mazzamurro, F, Barchetti, F, Staltari, I, Marini, M, Diagnostic Value of MR Enterography in the Detection of Small Bowel Polyps in the Peutz-Jeghers Syndrome.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11011628.html