Sachiko Miura MD, Presenter: Nothing to Disclose

Kaoru Hamada MD,PHD, Abstract Co-Author: Nothing to Disclose

Takayuki Shinkai MD, Abstract Co-Author: Nothing to Disclose

Masatoshi Hasegawa, Abstract Co-Author: Nothing to Disclose

Kimihiko Kichikawa MD, Abstract Co-Author: Nothing to Disclose

Toshihide Itoh, Abstract Co-Author: Employee, Siemens AG

To investigate whether lung perfused blood volume (PBV) imaging with dual source dual energy CT (DECT) can detect findings of pulmonary hypertension (PH)

 Retrospectively selected 20 patients who underwent DECT were enrolled. 10 of those had no PH or any lung disease, but rest 7 had pulmonary arterial hypertension (idiopathic 2, associated with connective tissue diseases 4, congenital heart disease 1) and 3 had PH owing to lung diseases or hypoxia (chronic obstructive pulmonary disease 1, interstitial lung disease 1, alveolar hypoventilation disorders 1). Lung PBV images were generated and normalized to compare with each patient. Lung field was divided into 5 segments along the craniocaudal axis with same length at right and left lungs and only central 3 segments (upper, middle and lower) were selected for analysis in terms of avoiding artifacts or influences of diaphragm, and each of those 3 segments was divided into 2 segments (anterior and posterior) along the anteroposterior axis as well. Averages of normalized PBV (nPBV) value in each segment were compared at non-PH group and PH group respectively, 1) between anterior and posterior segments, 2) among upper, middle and lower segments.

At non-PH group, nPBV was significantly higher (p<0.05), 1) at posterior than anterior at 5 of 6 segments, except for left upper, 2) at middle and lower than upper at 3 segments, right upper-middle, left upper-middle and left upper-lower. At PH group, deviation of nPBV was clearly larger than that at non-PH group, and nPBV was significantly higher (p<0.05), 1) at posterior than anterior at 2 of 6 segments, right and left lower, 2) at middle than upper at only 1 segment, left upper-middle .

nPBV showed correspondent with physiologic blood volume distribution at non-PH group. On the other hand, that distribution tended to disappear on nPBV at PH group as similar to findings of pulmonary perfusion scintigraphy. Lung PBV has a potential to detect findings of pulmonary hypertension.

Lung PBV imaging with DECT may be useful for detection of pulmonary hypertension.

Miura, S, Hamada, K, Shinkai, T, Hasegawa, M, Kichikawa, K, Itoh, T, The Detection of Pulmonary Hypertension Using Lung-perfused Blood Volume with Dual-Source Dual-Energy CT.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11011480.html