Joo Yeon Cheung MD, Presenter: Nothing to Disclose

Hak Hee Kim MD, Abstract Co-Author: Nothing to Disclose

Hyunji Kim MD, Abstract Co-Author: Nothing to Disclose

Jin Hee Moon MD, Abstract Co-Author: Nothing to Disclose

Hee Jung Shin MD, Abstract Co-Author: Nothing to Disclose

Joo Hee Cha, Abstract Co-Author: Nothing to Disclose

To investigate the correlation between immunohistochemical factors of breast cancer related to prognosis and physiological parameters of tumor using optical tomography with US localization.

Between September 2009 and March 2011, retrospectively evaluated 50 women (mean age, 61.5 years; age range 33-65 years) who diagnosed breast cancer and finally underwent operation. Before the operation, they were scanned with a combined imager.The hand-held probe, which consisted of a centrally located US transducer surrounded by near infrared sensors, was used to simultaneously acquire US images and optical data. Frome these measurements, physiological parameters of tumor including total hemoglobin concentration (HBT) , tissue oxygen saturation(SO2) , synthesis diagnostic index (SDI) were calculated. The immuohistochemical factors were assessed from operative pathologic reports. A student T-test  were used to calculate the statistical significance of mean HBT , SO2, SDI obtained in tumors, and P < 0.05 was considered to indicate a statistically significant difference.

The mean HBT and SDI in high grade group of nuclear and histologic grade (0.287 ± 0.081 μmol/L X 10³, 0.280 ± 0.065) were significantly higher than in intermediate grade group (0.287 ± 0.081 μmol/L X 10³, 0.280 ± 0.065) .The mean HBT and SDI were significant higher in negative group of estrogen receptor (0.301 ± 0.071 μmol/L X 10³, 0.292 ±0.063) than positive group (0.219 ±0.093 μmol/L X 10³, 0.232 ±0.068). The mean HBT and SDI were higher in positive groups of CK5/6, P53, Ki-67 (0.313 ± 0.084 μmol/L X 10³, 0.285 ± 0.082 μmol/L X 10³, 0.281 ±0.089 μmol/L X 10³ ; 0.301±0.065, 0.282±0.061, 0.277±0.068) than negative groups (0.229 ±0.087 μmol/L X 10³, 0.234 ±0.095 μmol/L X 10³, 0.205 ±0.082 μmol/L X 10³; 0.239±0.067, 0.241±0.074, 0.221±0.066) with statiscally significance. The mean HBT was higher in negative group of progesteron receptor (0.257 ±0.092 μmol/L X 10³) than positive group (0.239 ±0.098 μmol/L X 10³), but there was no statistical significance (P > 0.05). The HER-1 and HER-2 showed no significant correlation with HBT and SDI. There were no statistical significance between SO2 and immunohistochemical factors.

Optical tomography with US localization can predict the prognosis factors of breast cancer.

Optical tomography with US localization can predict prognosis factors of breast cancer.

Cheung, J, Kim, H, Kim, H, Moon, J, Shin, H, Cha, J, Predicting Prognosis Factors of Breast Cancer Using Optical Tomography with Ultrasonographic (US) Localization.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11011171.html