Clarisse Dromain MD, Presenter: Nothing to Disclose

Sandra Canale, Abstract Co-Author: Nothing to Disclose

Francois Bidault MD, Abstract Co-Author: Nothing to Disclose

Mahasti Saghatchian, Abstract Co-Author: Nothing to Disclose

Marie-Christine Mathieu MD, Abstract Co-Author: Nothing to Disclose

Corinne Balleyguier MD, Abstract Co-Author: Nothing to Disclose

To assess and compare the diagnostic accuracy of CESM and MRI to assess the extent of breast cancers

After ethics committee approval, 42 consenting patients with newly diagnosed breast cancer were imaged with CESM and MRI. Bi-lateral CESM examinations were performed using a GE Healthcare (Chalfont St-Giles, UK) Senographe DS system, modified for paired dual energy exposures. Intra-venous injection of iodinated contrast agent (350mg I/ml) followed a standard CT protocol (1.5ml/kg of body weight at 3ml/s rate). Individual interpretations of MRI and CESM images were performed by two different experienced breast radiologists. Truth was determined by histology in all cases

37 patients were analyzed. For detection of primary tumor, sensitivity was 95% (35/37) for CESM and 100% (37/37) for MRI. For detection of additional foci, sensitivity was 88% (22/25) for CESM and 92% (23/25) for MRI. Specificity was 98% for CESM and 92% for MRI with 1 and 5 false positives, respectively. Four DCIS were depicted on low-energy CESM images without obvious contrast enhancement. The false negatives for additional foci were three ILC (median size 10mm) for CESM and two ILC (median size 11mm) for MRI.

This preliminary study shows that CESM performs with good diagnostic accuracy in assessing the extent of breast cancers with sensitivity slightly inferior and specificity slightly superior compared to MRI

CESM is useful for assessing the extent of breast cancers  

Dromain, C, Canale, S, Bidault, F, Saghatchian, M, Mathieu, M, Balleyguier, C, Value of Contrast-enhanced Spectral Mammography (CESM) in Women with Newly Diagnosed Breast Cancers Compared to MRI: Preliminary Results.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11009315.html