Jing Liu, Presenter: Nothing to Disclose

Xuedong Yang, Abstract Co-Author: Nothing to Disclose

Xiaoying Wang MD, Abstract Co-Author: Nothing to Disclose

Feiyu Li MD, Abstract Co-Author: Nothing to Disclose

Xuexiang Jiang, Abstract Co-Author: Nothing to Disclose

To explore the role of DWWB in detecting metastatic lesions in whole body of patients with clear cell RCC (rrRCC) and monitoring treatment response of metastases, comparing with chest CT and routine MR

10 patients (9 men and 1 woman; mean age=55years) with histologically confirmed ccRCC and possible metastatic lesions were underwent standard DWWB, chest CT and routine MR examinations before and 60 days after chemotherapy, respectively. The drugs administrated to patients were the same. The DWI protocol was a STIR-EPI single shot acquisition in 7 station series, TR/TE of 4300/57.6 ms; TI of 160ms. Diffusion gradients with two b values (0 and 600 s/mm2) were applied along three directions. Whole-body T1-dual echo sequence was also acquired for each patient in order to provide an anatomical template. Abnormal high signal intensities on DWI were considered as metastases using chest CT, conventional T1- and T2WI in abdomen and pelvis as reference.Maximal diameters of metastases were measured on images of whole-body T1 dual echo, as well as chest CT and T2WI for treatment response monitoring. And the sizes metastases were compared among multiple metastases in the lung, bone and lymph nodes. In the mean time, apparent diffusion coefficient (ADC) values of metastases were measured on DWI  

Metastases were detected in the lung (8 cases), bone (3), muscle (3) and lymph node (1). For the images before chemotherapy, 6 and 8 patients with pulmonary metastases showed positive on DWWB. And all of metastases excluding lung detected by DWWB were in accordance with conventional T1- and T2- weighted images.For comparison before and after chemotherapy, the size changes of metastases detected by whole-body T1were in accordance with chest CT and conventional T2WI. Average ADC values of pulmonary metastases which showed reduced in sizes significantly increased from 1.01 to 1.79×10-3mm2/s (P<0.01), while average ADC value of pulmonary metastases which showed increased in sizes significantly dropped from 1.31 to 0.92×10-3 mm2/s (P<0.01)

DWWB showed high sensitivity in detecting metastases in whole body, even in the lung. And it showed great potential application in monitoring metastatic lesions under chemotherapy as well.

the effects of whole-body DWI in detecting metastatic lesions in whole body of patients with clear cell RCC and monitoring treatment response of metastases

Liu, J, Yang, X, Wang, X, Li, F, Jiang, X, Preliminary Study of Whole-Body Diffusion-weighted Imaging (DWWB) in Metastases Detecting and Treatment Response Monitoring in Patients with Clear Cell Renal Cell Carcinoma (RCC).  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11007489.html