Min Sun Bae, Presenter: Nothing to Disclose

Hye Ryoung Koo MD, Abstract Co-Author: Nothing to Disclose

Woo Kyung Moon, Abstract Co-Author: Nothing to Disclose

Nariya Cho MD, Abstract Co-Author: Nothing to Disclose

Jung Min Chang MD, Abstract Co-Author: Nothing to Disclose

Ann Yi MD, Abstract Co-Author: Nothing to Disclose

To evaluate the clinicopathologic characteristics of US-detected breast cancer in the screened women compared with mammography-detected cancer.

A search of the database for patients with the breast cancer between September 2003 and April 2010 yielded a data set in 6837 women who underwent breast surgery at our hospital. Of 6837 women, 1047 were asymptomatic and had a non-palpable cancer based on the clinical record review. 254 women with 256 cancers detected by US (US-detected cancer) and 793 women with 807 cancers detected by mammography (MG-detected cancer) were identified. The clinical, imaging, pathological and immunohistochemical data were reviewed. Univariate and multivariate analyses were performed.

Women with US-detected cancer were slightly younger (mean age 48 vs 52 years; p < 0.0001) and were more likely to undergo a breast-conserving surgery (84.4 vs 68.4%; p < 0.0001) and to have a node-negative invasive cancer (91.8 vs 84.1%, 81.2 vs 73.5%; p < 0.0001). At multivariate logistic regression analysis, significant independent characteristics of the US-detected cancer were the tumor size, mammographic density, final BI-RADS assessment category, PR, HER2 and luminal subtype. Compared to tumors that were > 2cm in size, tumors that were ≤ 1cm in size were 2.2 times more likely to be US-detected cancers (p=0.02). Compared to the luminal A subtype tumors (ER+, PR+, HER2-), luminal B subtype tumors (ER+, PR+, HER2+) were less likely to be in the US-detected cancer group (p<0.01). Women with dense breasts (mammographic density of 50% or more) were 3.7 times more likely to have US-detected cancer (p<0.01) versus those with non-dense breasts (mammographic density less than 50%). US-detected cancers were less likely than MG-detected cancers to be diagnosed as category 5 instead of category 4 (p<0.01).

Women with US-detected breast cancer are more likely to have a small-sized invasive cancer and a more favorable molecular phenotype.

Breast cancer detected by supplemental US screening can benefit from early detection, which would allow breast conservation and the use of less toxic therapy.

Bae, M, Koo, H, Moon, W, Cho, N, Chang, J, Yi, A, Clinicopathologic Characteristics of Breast Cancers Detected by Screening Ultrasound.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11006800.html