Hiroyuki Takaoka MD, PhD, Presenter: Nothing to Disclose

Nobusada Funabashi MD, PhD, Abstract Co-Author: Nothing to Disclose

Raghav Raman MD, Abstract Co-Author: Nothing to Disclose

Bhargav Raman MD, Abstract Co-Author: Nothing to Disclose

Sandy Napel PhD, Abstract Co-Author: Medical Advisory Board, Fovia, Inc Consultant, Carestream Health, Inc

Geoffrey D. Rubin MD, Abstract Co-Author: Medical Advisory Board, Fovia, Inc Advisory Board, General Electric Company Consultant, Medtronic, Inc Consultant, TeraRecon, Inc

Masae Uehara MD, Abstract Co-Author: Nothing to Disclose

Kenichi Fukushima, Abstract Co-Author: Nothing to Disclose

Yoshio Kobayashi, Abstract Co-Author: Nothing to Disclose

To detect >75% luminal stenosis in quantitative coronary angiography (QCA), we evaluated iodinate contrast opacification gradients in coronary arteries with regard to distance from the ostium by 320-slice CT.

Fifty-seven consecutive subjects (42 male, 62.7±11.9 yrs) who underwent both QCA and 320-slice CT (Aquilion one, Toshiba Medical) were analyzed. Thirty subjects had >50% luminal stenosis on QCA in at least one vessel. We measured CT values in coronary arterial lumens with the distance from the ostium at 0.5mm intervals in all coronary arteries. If there was no significant stenosis in vessels, vessels were divided into proximal half (lesion P) and distal half lesions (lesion D) based on the distance between the proximal ostium and the distal end of the lesion. If there was stenosis, vessels were divided into proximal (lesion P) and distal lesions (lesion D) relative to the stenosis (Figure). We calculated the ratios of mean CT values of lesion D to those of lesion P in all cases. From the scatter plot of distance from the ostium (X axis) versus CT values in the coronary lumen (Y axis), the minimum slopes (MS) were analyzed.

The ratios of CT values in lesion D/P were 0.71±0.16 in the left coronary artery (LCA), 0.76±0.23 in the RCA, and 0.72±0.17 in both arteries with significant stenosis, which were lower than in arteries with no significant stenosis (0.76±0.12 in the LCA, p=0.08; 0.93±0.07 in the RCA, p=0.05; and 0.82±0.13 in both; p<0.01). The MSs were -1.30±1.28 in the LCA, -1.10±1.53 in the RCA, and -1.25±1.32 in both arteries with significant stenosis, which were lower than in arteries with no significant stenosis (-0.83±0.48 in the LCA, p=0.12; -0.37±0.46 in the RCA, p=0.22; and -0.68±0.52 in both, p<0.05).

The difference of CT values between lesion D and P, and the MSs of CT values in the coronary lumen with regard to distance from the ostium by 320-slice CT, were significantly lower in vessels with >75% stenosis in QCA than in those without significant stenosis.

The measurement of CT values in coronary arterial lumens, may be useful for the prediction of >75% stenosis in QCA.

Takaoka, H, Funabashi, N, Raman, R, Raman, B, Napel, S, Rubin, G, Uehara, M, Fukushima, K, Kobayashi, Y, Detection of >75% Stenosis in Quantitative Coronary Angiography by Iodinate Contrast Opacification Gradients in Coronary Artery with Regard to Distance from the Ostium by 320 Slice Computed Tomography.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11005266.html