Rakesh Kumar Gupta, Presenter: Nothing to Disclose

J Rajiv Bapuraj MD, Abstract Co-Author: Nothing to Disclose

N. Khandelwal, Abstract Co-Author: Nothing to Disclose

To Determine the CT perfusion parameters in patients of cerebral venous sinus thrombosis (CVST) and to assess the change in perfusion parameters after treatment.

20 patients of CVST diagnosed on basis of NCCT, MRI, MRV were included in the study. Initial CT perfusion was performed at time of admission. Perfusion parameters relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV) and relative mean transit time (rMTT) were calculated in core and periphery of affected area. Follow up CT perfusion was done at 1 month and perfusion parameters were compared with initial perfusion parameters. Receiver operating characteristic (ROC) curve analysis was performed to determine the prognostic significance of perfusion parameters

All the 20 patients with diagnosis of CVST showed areas of hypoperfusion on CT perfusion. rCBF, rCBV were reduced and rMTT was prolonged in core and periphery of lesion. There was significant overlap of perfusion parameters in core and periphery of lesion. ROC curve analysis showed the optimal threshold for rCBF > 60.5%, rCBV > 75.5%, & rMTT <148.5%. Post treatment perfusion parameters showed significant correlation in core of the lesion (P<0.05)

CT perfusion study in CVST is a good prognostic tool and yield valuable information regarding clinical outcome on basis of perfusion parameters.

CT perfusion can be used as a prognostic tool in CVST

Gupta, R, Bapuraj, J, Khandelwal, N, CT Perfusion in Cerebral Venous Sinus Thrombosis:  A Prospective Study .  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11004226.html