Christof M Sommer MD, ARRT, Presenter: Nothing to Disclose

Ulrike Stampfl, Abstract Co-Author: Nothing to Disclose

Nadine Bellemann, Abstract Co-Author: Nothing to Disclose

Maria Holzschuh, Abstract Co-Author: Nothing to Disclose

Alexander Kueller, Abstract Co-Author: Researcher, Celonova Biosciences

Jaques Bluemmel, Abstract Co-Author: Researcher, Celonova Biosciences

Tobias Gehrig, Abstract Co-Author: Nothing to Disclose

Maxym Shevchenko, Abstract Co-Author: Nothing to Disclose

Hannes G Kenngott, Abstract Co-Author: Nothing to Disclose

Hans-Ulrich Kauczor MD, Abstract Co-Author: Research grant, Siemens AG Research grant, Boehringer Ingelheim GmbH Research Consultant, General Electric Company

Boris A. Radeleff MD, Abstract Co-Author: Nothing to Disclose

To evaluate multimodal visibility of embolization particles on Angiography, CT and MRI in porcine kidneys.

As an evolution of the current available embolization particles (Embozene™ Microspheres, CeloNova BioSciences, USA), those particles were modified, that additional embedding of a dense X-ray material should result in good visibility on Angiography and CT as well as additional embedding of a magnetic substance should result in good visibility on MRI. Three different prototypes (Intensity A, B and C) as well as current available Embozene™ Microspheres with sizes of 100±25µm and 700±100µm were tested. Without using any contrast material, renal arteries of four pigs were catheterized and each kidney was embolized with one milliliter of one type of particle. Subjective and objective particle visibility was evaluated on Angiography, CT and MRI.

On Angiography, Intensity A, B and C of 100±25µm particles as well as Intensity B of 700±100µm particles were definitely visible. Current available Embozene™ Microspheres given as control group were definitely not visible. On CT and MRI (T1 and T2), Intensity A, B and C of 100±25µm particles as well as 700±100µm particles were definitely visible. On CT, signal-to-noise ratio for Intensity A, B and C increased significantly (e.g. Intensity A, 100±25µm particles: +66.5±23.7%, P<0.05). On MRI (T1 and T2), signal-to-noise ratio for Intensity A, B and C decreased significantly (e.g. Intensity B, 700±100µm particles, T1: -73.0±8.9%, P<0.05).

Modification of the current available Embozene™ Microspheres was successful with multimodal visibility on Angiography, CT and MRI.

Multimodal visibility of embolization particles might increase the oncological success. 

Sommer, C, Stampfl, U, Bellemann, N, Holzschuh, M, Kueller, A, Bluemmel, J, Gehrig, T, Shevchenko, M, Kenngott, H, Kauczor, H, Radeleff, B, Multimodal Visibility (Angiography, CT and MRI) of Embolization Particles: A Feasibility Study in Porcine Kidneys.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11004070.html