Bing Zhang, Presenter: Nothing to Disclose

Bin Zhu MD, PhD, Abstract Co-Author: Nothing to Disclose

Ming Li, Abstract Co-Author: Nothing to Disclose

To evaluate Brain Search (BS) software based on anatomical volumes of interest (AVOI) for ADC maps, designed by authors of this article.

The study was acquired by the 1.5-T MRI scanner (Philips Intera Master) with a standard quadrature head coil. According to exclusion criteria and quality control for ADC maps, 25 with AD (7F/18M, 67.0±7.9 years old), 26 with aMCI (9F/17M, 69.4±7.4 years old), and 18 normal controls (6F/12M, 64.7±8.8 years old) were recruited (Petersen and NINCDS/ADRDA criteria). EPI sequence of DWI with FLAIR was adopted with TR/TI/TE=6000/1900/95 ms, b=1000 ms/mm2, an in plane resolution of 2.0 mm and a slice thickness of 2.5mm. The independent ADC map was analyzed by using Brain Search (BS). 90 of regional parcellation were adopted in BS by using the automated anatomic labeling (AAL) atlas.

ADC values in hippocampus and posterior cingulate among NC, aMCI and AD groups were significantly different  by single ROI method. Abnormalities in ADC maps in aMCI and AD compared to NC were observed by BS as follows. The ADC obviously elevated in aMCI than NC in the limbic cortex (Hippocampus_L, ParaHippocampal_L, Insula_R), etc. And between aMCI and AD, the statistical different brains areas of ADC values included the limbic cortex (Hippocampus_R), Bilateral Temporal_Pole_Sup, etc. Furthermore, between AD and NC, besides the bilateral hippocampus, significantly different brain areas extended to surrounding limbic system and related cortex (Cingulum_Mid_R, ParaHippocampal_R, Insula_R, ect). There had been a negative correlation between the water diffusivity and MMSE, MoCA, Digit-symbol coding, Digit span, Raven's IQ, WAIS IQ. The water diffusivity was positive correlation with CDR, ADL, ADAS-Cog.

The water diffusivity in aMCI and AD than NC had asymmetry anatomical lateralization. The pattern of water diffusivity in hippocampal and parahippocampal was initially leftward involvement, progressing to bilateral involvement and extending rightward lateralization in the later stage of AD. The water diffusivity alterations in the limbic cortex and Papez circuit among groups were shown in an intuitive way by BS.

Measures of apparent diffusion coefficient (ADC)  can quantify the alterations in water diffusivity resulting from microscopic structural changes caused by aMCI and Alzheimer’s disease (AD).

Zhang, B, Zhu, B, Li, M, Evaluation of Apparent Diffusion Coefficient (ADC) Map in Amnestic Mild Cognitive Impairment (aMCI) by Using Image Analysis Software Named Brain Search Based on Anatomical Volumes of Interest (AVOI).  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11001227.html