Norio Hayashi PhD, Presenter: Nothing to Disclose

Mitsuru Kikuchi, Abstract Co-Author: Nothing to Disclose

Shigeru Sanada PhD, Abstract Co-Author: Stockholder, Hologic, Inc

Yoshio Minabe, Abstract Co-Author: Nothing to Disclose

Tosiaki Miyati PhD, Abstract Co-Author: Nothing to Disclose

Osamu Matsui MD, Abstract Co-Author: Research Consultant, Bayer AG Research grant, Bayer AG Research Consultant, Eisai Co, Ltd Research Consultant, Kowa Company, Ltd

Ayaka Miyagishi, Abstract Co-Author: Nothing to Disclose

Masako Takanaga, Abstract Co-Author: Nothing to Disclose

Takashi Hamaguchi MS, Abstract Co-Author: Nothing to Disclose

Naoki Ohno MS, Abstract Co-Author: Nothing to Disclose

Keita Sakuta RT, Abstract Co-Author: Nothing to Disclose

Kaori Minehiro, Abstract Co-Author: Nothing to Disclose

Hiroki Kawashima BS, RT, Abstract Co-Author: Nothing to Disclose

We developed a method for creation of a personalized brain template for superimposition of MEG or NIRS without MR imaging. Using this technique, the MEG and NIRS data could be accurately superimposed on the brain surface without performing MRI for mapping.

We have developed a magnetoencephalography (MEG) and near-infrared spectroscopy (NIRS) method for early detection of pediatric psychiatric disorders, such as Asperger’s syndrome. Mapping of these data on MR imaging (MRI) results is necessary for accurate analysis. However, it is difficult to obtain additional MR images in children with sedation. This study was performed to develop a method for creation of a personalized brain template to allow superimposition of MEG or NIRS without MR imaging.

Institutional review board approval and written informed consent were obtained. Forty subjects (16 male, 25 female, mean age 22.5 years, range 15 – 38 years) in whom no abnormalities were observed on 3.0 Tesla MRI were included in this study. For evaluation, 20 subjects underwent MEG. Our method for creation of the brain template consisted of the following four steps: 1) plotting of five points on the head surface; 2) selection of suitable template data; 3) registration of the template to personalized data; and 4) superimposition of the MEG data on the personalized brain template. Accuracy was evaluated according to the following two steps: 1) the results of MEG examination were plotted on the same subject’s MRI and developed a personalized brain template, and 2) error was calculated as the difference between the subject’s MRI selected at random and the developed template using root mean square error (RMSE).

The plot error between on the same subject and the created template was 9.7 ± 4.6 mm. The RMSE using the created brain template was significantly smaller in comparison to that in one subject selected at random (P < 0.05).

Hayashi, N, Kikuchi, M, Sanada, S, Minabe, Y, Miyati, T, Matsui, O, Miyagishi, A, Takanaga, M, Hamaguchi, T, Ohno, N, Sakuta, K, Minehiro, K, Kawashima, H, Development of Method for Creation of a Personalized Brain Template to Allow Superimposition of MEG and NIRS.  Radiological Society of North America 2011 Scientific Assembly and Annual Meeting, November 26 - December 2, 2011 ,Chicago IL. http://archive.rsna.org/2011/11000610.html