Henry Soo-Min Park BS, Presenter: Nothing to Disclose

Jonathan P. S. Knisely MD, Abstract Co-Author: Nothing to Disclose

Veronica Chiang MD, Abstract Co-Author: Nothing to Disclose

James Byunghoon Yu MD, Abstract Co-Author: Nothing to Disclose

Introduction:"Central nervous system (CNS) meningiomas are common and usually benign tumors that constitute approximately 15% of adult CNS tumors. Fractionated radiation therapy (FRT) and stereotactic radiosurgery (SRS) are often used in conjunction with surgery or as a primary treatment. There may be increased side effects from treatment when critical structures are located nearby, such as the optic nerve, optic chiasm, pituitary gland, or pituitary stalk, as is the case for base-of-skull CNS meningiomas (BOSM). Therefore, we performed a survey of patients who underwent radiotherapy for BOSM."Methods: "Using the SF-12v2 general health quality of life (QoL) survey, and the National Eye Institute Visual Functioning Questionnaire (VFQ-25) we assessed QoL and visual function (VF) after radiation. Patients who underwent radiation at a single institution were contacted over the phone. Mental health composite (MHC) scale and physical health composite (PHC) scale scores were calculated using the SF-12v2. VFQ-25 overall composite score (CS) was calculated, as were the subdomains for general vision, ocular pain, near activities, distance activities, vision-specific social functioning, vision-specific mental health, vision-specific role difficulties, vision-specific dependency, driving, color vision, and peripheral vision. A review of the literature shows that the mean CS for a patient with normal vision is > 90."Results:"Fourteen women and 7 men were interviewed. Median age at treatment was 54 years (range 30-83). Median time from treatment to survey was 5.6 years (range 3.3-10.7). Five underwent FRT and 16 underwent SRS. Mean MHC was 55.8 (SE 2.0) for SRS, and 48.6 (SE 3.0) for FRT (two-sided t-test, p=0.0785). Mean PHC was 44.1 (SE 3.3) for SRS, and 51.3 (SE 4.1) for FRT (two-sided t-test, p=0.272). Overall CS was 80.3 (SE 3.8), and was significantly different compared to the normal CS of 90 (two-sided t-test, p=0.01). The worst mean subdomains were the “vision-specific role difficulties” (mean 71.4 [SE 6.9]) and “general vision” (mean 72.4 [SE 5.3]). The best mean subdomains were “vision-specific social functioning” (mean 90.5 [SE 5.0]) and “color vision” (mean 91.7 [SE 5.0])."Conclusions:"Patients who undergo radiotherapy for BOSM have significantly worse self-reported vision-targeted health status compared to the historical normal population. Patients retain social functioning and color vision, but experience difficulty with vision-specific roles and general vision. There is also a trend to worse general mental health for FRT compared to SRS."

Park, H, Knisely, J, Chiang, V, Yu, J, Quality of Life and Visual Function after Radiation for Skull Base Meningioma.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9020158.html