Shen Ping Yu, Presenter: Nothing to Disclose

Li He, Abstract Co-Author: Nothing to Disclose

Xiaozhao Zhuang, Abstract Co-Author: Nothing to Disclose

Boning Luo, Abstract Co-Author: Nothing to Disclose

To evaluate the differentiation of metastatic from nonmetastatic lymph nodes with diffusion-weighted imaging (DWI) at 3T in cervical cancers.

DWI of 25 patients with cervical cancer underwent hysterectomy and pelvic lymph node dissection were analyzed retrospectively. The metastatic and nonmetastatic lymph nodes were proven by operation and histology. Apparent diffusion coefficient (ADC) values, long-axis diameters, short-axis diameters, and the ratio of short/long-axis diameters of all the identifiable lymph nodes were measured. The student t-test was used to compare the data of metastatic and nonmetastatic lymph nodes. And the Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff values.

17 metastatic lymph nodes and 140 non-metastatic lymph nodes were confirmed combined with operation and histology in 25 cases of the patients with cervical cancer. The ADC value of metastatic and nonmetastatic lymph nodes were 0.86±0.36×10-3 mm2/s and 1.12±0.34×10-3 mm2/s respectively. The long-axis diameter, short-axis diameter, the ratio of short/long-axis diameter of metastatic and nonmetastatic lymph nodes were 1.51±0.41cm and 1.19±0.36cm, 1.16±0.35cm and 0.77±0.22cm, 0.78±0.17 and 0.68±0.19 respectively. There was statistically significant difference between metastatic and nonmetastatic lymph nodes in ADC value, long-axis diameter, short-axis diameter, the ratio of shor/long-axis diameter. The area under ROC curve of ADC value, long-axis diameter, short-axis diameter, the ratio of short/ long-axis diameter were 0.19, 0.73, 0.83 and 0.66 respectively. The cutoff value of which to differentiate metastatic and nonmetastatic lymph nodes were 0.83×10-3 mm2/s, 1.30cm, 0.90cm and 0.75 respectively.

ADC value, long-axis diameter, short-axis diameter，the ratio of short/long-axis diameter may be used to differentiate metastatic and nonmetastatic lymph nodes cervical cancer. Short-axis diameter was the best with cutoff value 0.90cm.

Diffusion-weighted imaging (DWI) can be used to detect metastatic lymph nodes in cervical cancer.

Yu, S, He, L, Zhuang, X, Luo, B, Differentiation of Metastatic from Nonmetastatic Lymph Nodes in Cervical Cancers: Pilot Study by Diffusion-weighted Imaging at 3T.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9015977.html