Kyoung Won Kim MD, Presenter: Nothing to Disclose

Pyo Nyun Kim MD, Abstract Co-Author: Nothing to Disclose

Ji Hoon Shin MD, Abstract Co-Author: Nothing to Disclose

Woo Kyoung Jeong MD, Abstract Co-Author: Nothing to Disclose

Hyung Jin Won MD, Abstract Co-Author: Nothing to Disclose

Yong Moon Shin MD, Abstract Co-Author: Nothing to Disclose

Won Jae Lee MD, Abstract Co-Author: Nothing to Disclose

Moon Gyu Lee, Abstract Co-Author: Nothing to Disclose

Gi-Won Song, Abstract Co-Author: Nothing to Disclose

Shin Hwang MD, Abstract Co-Author: Nothing to Disclose

Sung Gyu Lee MD, Abstract Co-Author: Nothing to Disclose

To compare time-enhancement curve parameters of contrast-enhanced ultrasound(CEUS) in acute partial hepatic venous-outflow obstruction(HVO) with those of baseline study.

CEUS was performed in 11 rabbits, with bolus administration of 0.1 mL/Kg of SonoVueTM. After obtaining baseline scan for 3 minutes, 5.3-F balloon catheter was placed into hepatic vein. Partial HVO was artificially induced by 0.4 mL balloon inflation, and CEUS was repeatedly performed thereafter. On images stored with 1-sec intervals, 2•2 mm ROIs were placed and mean luminosity was measured. Time-enhancement curves were plotted and contrast-arrival time(TA), peak enhancement value(EP), peak enhancement time(TP), 50% wash-out time(W50%), and 3-min wash-out rate(W3MIN) were obtained. Paired t-tests were performed to evaluate statistical significance in differences of the above parameters between baseline study and those with HVO.

On baseline CEUS, medians of TA, EP, TP, W50%, and W3MIN were 6(range, 4−8; mean±standard deviation, 5.9±1.2), 188.5(104.7−209.5, 178.4±33.1), 19(14−27, 19.8±4.1), 75(60−101, 78.2±13.9), and 89.7(81.3−95.1, 88.4±4.9). Those values were 7(5−12, 6.9±2.3), 202.8(98.2−215.1, 186.0±39.3), 31(17−59, 32±11.6), 101(47−136, 96.2±23.6), and 79.2(66.2−88.8, 79.1±7.6) with HVO. TP and W50% were significantly delayed (P=.0027,=.0209) and W3MIN was significantly decreased (P<.0001) on CEUS with HVO, compared with baseline study, but there were no significant differences in TA and EP (P=.0756,.2179).

CEUS can provide quantitative assessment for microbubble congestion in HVO. TP and W50% are delayed and W3MIN is decreased on CEUS in rabbits with artificially induced acute partial HVO, compared with baseline study.

Contrast-enhanced ultrasound may be used in the diagnosis of acute hepatic-venous outflow obstruction after liver transplantation, providing quantitative assessment for the congestion of microbubbles.

Kim, K, Kim, P, Shin, J, Jeong, W, Won, H, Shin, Y, Lee, W, Lee, M, Song, G, Hwang, S, Lee, S, Acute Outflow Obstruction of Hepatic Veins in Rabbits: Quantitative Analysis of Hepatic Perfusion on Contrast-enhanced Ultrasound.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9015244.html