Shen Ping Yu, Presenter: Nothing to Disclose

Li Jiang MD, PhD, Abstract Co-Author: Nothing to Disclose

Quanfei Meng MD, Abstract Co-Author: Nothing to Disclose

Yanling Zhang, Abstract Co-Author: Nothing to Disclose

To evalue the accuracy of MR perfusion imaging at 3T in measuring the hemodynamics of liver.

64-slice spiral CT perfusion imaging and MR perfusion imaging at 3T were performed in livers of 13 pigs. The hepatic artery perfusion (HAP), portal vein perfusion (PVP), total hepatic blood flow (THBF), portal vein perfusion index (PVI), distribution volume (DV) and mean transit time (MTT) were calculated and compared respectively. Hemodynamics of the liver from two kinds of imaging was compared by paired t-test, and the relativity weas analyzed by Pearson correlation analysis. Transcatheter arterial embolization (TAE) were performed in 8 pigs, and MR perfusion imaging of liver were performed before and 3 days, 1 week after the operation respectively. Liver perfusion parameters were calculated and compared respectively.

In CT and MR perfusion imaging of the 13 pigs: HAP were (37.71 ± 7.38) and (35.80 ± 7.31) ml•min-1•100 ml-1, PVP were (123.16 ± 35.89) and (121.40 ± 36.81) ml•min-1•100 ml-1, THBF were (160.88 ± 37.05) and (157.21 ± 38.71) ml•min-1•100 ml-1, PVI were (75.95 ± 5.21) % and (76.63±5.24)%, DV were (35.10 ± 11.17)% and (41.03 ± 10.06)%, MTT were (14.08 ± 1.40) and (14.94 ± 1.32)s. There weren no statistical difference for HAP, PVP, THBF and PVI between CT and MR perfusion imaging (t= 1.263, 0.926, 1.225, 1.115, P>0.05). There were statistical difference for DV and MTT (t=-3.345, -3.200, P<0.01). Analysis of these two kinds of imaging showed the correlation coefficient of PVP, THBF and PVI were highly related (γ<0.85, p<0.01). Correlation coefficient of HAP, DV and MTT were moderately related (γ>0.70, p<0.01). There were changes for the hepatic hemodynamics measured by MR perfusion imaging in different time quantum before and after TAE.

MR perfusion imaging at 3T can quantify the hemodynamics of liver accurately. It is near to that of the 64-silice spiral CT perfusion imaging and may be used to detect the hemodynamical changes after TAE.

MR perfusion imaging at 3T may play potential and important role in diagnosis and treatment of liver diseases by measuring the hepatic hemodynamics.

Yu, S, Jiang, L, Meng, Q, Zhang, Y, Measuring the Hemodynamics of Liver in Pigs with MR Perfusion Imaging at 3 T Evaluation and Compared with 64-silice Spiral CT.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9014769.html