Jin Woo Choi MD, Presenter: Nothing to Disclose

Chang Min Park, Abstract Co-Author: Nothing to Disclose

Sang Min Lee MD, Abstract Co-Author: Nothing to Disclose

Chang Hyun Lee MD, PhD, Abstract Co-Author: Editorial Consultant, Siemens AG, Korea

Jin Mo Goo MD, PhD, Abstract Co-Author: Research Consultant, Infinitt Healthcare Co., Ltd

Hyun Ju Lee MD, Abstract Co-Author: Nothing to Disclose

Yong Sub Song MD, Presenter: Nothing to Disclose

To retrospectively investigate clinical and CT features of transient part-solid nodules (PSNs) initially detected at high-risk population for lung cancer and to determine predictive factors which may differentiate transient PSNs from persistent PSNs.

From January 2006 to August 2008, we identified 42 individuals with 62 PSNs among 8,333 high-risk populations for lung cancer who underwent low-dose thin-section chest CT. We reviewed the CT characteristics of PSNs and the clinical features of these individuals and compared the clinical and thin-section CT features between transient and persistent PSNs. To identify predictive factors of transient PSNs, logistic regression analysis with generalized estimating equations was conducted. C-statistic was also performed to evaluate the predictive performance of the logistic regression model in discriminating transient from persistent PSNs.

Fifty-three of 62 PSNs (85.4%) were transient. Between transient and persistent PSNs, there were a significant difference in age, sex, presence of eosinophilia, lesion multiplicity, lesion margin and lesion border (P<0.005). At multivariate analysis, younger age, blood eosinophilia, and an ill-defined border were significant independent predictors of transient PSNs (P<0.05). The C-statistic showed that the performance of the logistic regression model using both clinical and thin-section CT features (AUC-value, 0.976) was significantly higher than those using clinical features alone or thin-section CT features alone in the discrimination of transient PSNs from persistent PSNs.

A substantial proportion of PSNs in high-risk population was transient. Transient PSNs and persistent PSNs could be distinguished with high accuracy using several clinical and thin-section CT features.

PSNs with characteristic findings of transient PSNs can be safely followed up in a short-term period even in high-risk patients for lung cancer.

Choi, J, Park, C, Lee, S, Lee, C, Goo, J, Lee, H, Song, Y, Transient Part-Solid Nodules in the Lung at Lung Cancer High-Risk Population: Comparison with Persistent Part-Solid Nodules.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9014569.html