Gilda Rechichi MD, Presenter: Nothing to Disclose

Stefania Galimberti, Abstract Co-Author: Nothing to Disclose

Anna Chiara Cadonici MD, Abstract Co-Author: Nothing to Disclose

Patrizia Perego, Abstract Co-Author: Nothing to Disclose

Maria Grazia Valsecchi, Abstract Co-Author: Nothing to Disclose

Sandro Sironi MD, Abstract Co-Author: Nothing to Disclose

To investigate a) whether ADC values of endometrial cancer differ from those of normal endometrium and myometrium, and b) whether they vary according to the histologic tumor grade and depth of myometrial invasion.

Seventy patients with histologically proven endometrial cancer (endometrial cancer group) and 36 with pathologically confirmed normal endometrium (control group) were enrolled in this prospective study. All patients underwent preoperative MR examination (including T2-weighted, dynamic T1-weighted and DW images with b-values of 0 and 1000 s/mm2) and then total hysterectomy. ADC measurements of endometrial cancer, normal endometrium and myometrium were performed on ADC map. Tumor type, grade (G1, G2, G3) and depth of myometrial invasion (no or <50% and >50%) were obtained from postoperative surgical histological findings.

The mean (+ SD) ADC value (10-3 mm2/sec) of endometrial cancer (0.77 + 0.12) was significantly lower than that of normal endometrium (1.31 + 0.11, p-value<0.0001) and normal myometrium (1.52 + 0.21, p-value<0.0001). When using a cut-off value of 1.05 10-3 mm2/s to distinguish normal endometrial tissue from endometrial carcinoma, sensitivity, specificity, and accuracy were 100%. The mean ADC value for each histologic grade was 0.79 + 0.08 (grade 1, n=14), 0.76 + 0.14 (grade 2, n=40), and 0.75 + 0.12 (grade 3, n=16), with no significant correlation between ADC and tumor grade (p-value=0.674). Comparing the mean ADC value of the 18 patients with more than 50% myometrial invasion (0.77 + 0.13) with the mean ADC value of the 52 patients with less than 50% invasion (0.76 + 0.12), the difference was not statistically significant (p-value=0.874).

.ADC measurements are feasible in differentiating between normal endometrium and endometrial carcinoma, and do not correlate with histologic tumor grade and depth of myometrial invasion.

ADC measurement is a helpful method in defining endometrial status (normal versus neoplastic). However, ADC measurments seem not to correlate with two important prognostic factors: histolo

Rechichi, G, Galimberti, S, Cadonici, A, Perego, P, Valsecchi, M, Sironi, S, Apparent Diffusion Coefficient in Endometrial Cancer: Correlation with Tumor Grading and Depth of Myometrial Invasion.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9013820.html