Chuanchen Zhang MD, Presenter: Nothing to Disclose

Zhaoqi Zhang, Abstract Co-Author: Nothing to Disclose

Lei Xu MD, PhD, Abstract Co-Author: Nothing to Disclose

Zixu Yan, Abstract Co-Author: Nothing to Disclose

Wei Yu MD, Abstract Co-Author: Nothing to Disclose

Xiaohai Ma MD, Abstract Co-Author: Nothing to Disclose

To evaluate the feasibility of CT myocardial perfusion imaging (CT-MPI) using 320-row CT volume scan.

Fourteen consecutive patients with positive radionuclide myocardial perfusion imaging (R-MPI) findings underwent CT rest and adenosine stress MPI. Rest and stress CT-MPI were analyzed by employing dedicated software in 320-row CT workstation. The software automatically calculated the transmural perfusion ratio (TPR, which was defined as mean segmental subendocardial density divided by mean density of entire subepicardial layer) of each segment and generated TPR based color coded maps to facilitate evaluation. Both R-MPI and CT-MPI were evaluated for fixed and reversible perfusion deficits using a 16-segment model (apex was excluded). The diagnostic performance of CT-MPI was evaluated with R-MPI as the standard of reference. The effective radiation dose for rest and stress MPI was estimated with a conversion coefficient for the chest 0.017.

Rest and stress CT-MPI were successfully performed in all patients. R-MPI depicted 39 segments with fixed or reversible perfusion deficits in total 14 patients, while CT-MPI identified 34 perfusion deficits in 12 patients. The sensitivity, specificity, positive predictive value, and negative predictive value of CT-MPI for the detection of perfusion deficits were 87.2%, 91.4%, 68.0%, and 97.1% in the per-segment analysis. The mean effective dose was 12.97 ± 2.51 mSv for CT-MPI.  

The preliminary results indicate that CT-MPI using 320-row CT volume scan is feasible for detection of fixed and reversible perfusion deficits.

320-row CT MPI is a promising strategy to detect fixed and reversible perfusion deficits, which is important to guide the optimal management of patients with coronary artery disease.

Zhang, C, Zhang, Z, Xu, L, Yan, Z, Yu, W, Ma, X, Preliminary Study of Myocardial Perfusion Imaging Using 320-Row Volume CT Scan.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9013406.html