Ali Mutsher Muhi MBChB, Presenter: Nothing to Disclose

Utaroh Motosugi MD, Abstract Co-Author: Nothing to Disclose

Tomoaki Ichikawa MD, PhD, Abstract Co-Author: Nothing to Disclose

Hironobu Sou MD, Abstract Co-Author: Nothing to Disclose

Katsuhiro Sano MD, Abstract Co-Author: Nothing to Disclose

Tsutomu Araki MD, Abstract Co-Author: Nothing to Disclose

To analyze the MR imaging variables for predicting tumor recurrence after curative surgical resection in hepatocellular carcinoma (HCC) patients.

A retrospective cohort study of 151 patients with HCC who underwent curative resection in our institution between January 2004 and December 2009 was conducted.After exclusion of patients who did not undergo MR images, a total of 118 patients were analyzed. Six imaging variables were evaluated including: tumor size, tumor proximity to portal and hepatic veins (distant (>5mm), close (1-4mm), adjacent, invasion), presence or absence of capsule, and tumor margins (smoothwell-defined margins or lobulated andirregular margins). Multivariate analysis of the imaging variables was performed using proportional hazard model. The annual recurrence rate was calculated using the Kaplan-Meier method.

Multivariate analysis of imaging variables indicated that ADC was the only statistically significant imaging variable for predicting early recurrence of HCC. The hazard ratio (95% confidence interval) was -3007.91 ± (-4907.18 to -1226.4). HCCs with ADC of ≤ 0.9 × 10-3 mm2/s have significantly higher annual recurrence rate (28%) than HCCs with ADC of > 0.9 × 10-3 mm2/s (3%) (P = 0.0002).

ADC can be used as an independent variable for predicting recurrence of HCC after curative resection.

Measurement of ADC can help predict the recurrence of HCC after curative surgical resection and thus it may influence the treatment of HCC patients.

Muhi, A, Motosugi, U, Ichikawa, T, Sou, H, Sano, K, Araki, T, Apparent Diffusion Coefficient of Hepatocellular Carcinoma: A Biomarker for Predicting Recurrence after Curative Surgical Hepatic Resection.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9013321.html