Baris I. Turkbey MD, Presenter: Nothing to Disclose

Haresh Mani, Abstract Co-Author: Nothing to Disclose

Vijay Shah PhD, MS, Abstract Co-Author: Nothing to Disclose

Marcelino Bernardo, Abstract Co-Author: Nothing to Disclose

Tom Pohida, Abstract Co-Author: Nothing to Disclose

Yuxi Pang PhD, Abstract Co-Author: Employee, Koninklijke Philips Electronics NV

Dagane Daar ARRT, Abstract Co-Author: Nothing to Disclose

Yolanda Mckinney, Abstract Co-Author: Nothing to Disclose

Maria Merino MD, Abstract Co-Author: Nothing to Disclose

Peter Pinto, Abstract Co-Author: Nothing to Disclose

Peter L. Choyke MD, Abstract Co-Author: Research agreement, Koninklijke Philips Electronics NV Research agreement, General Electric Company Research agreement, Siemens AG

The correlation between endorectal coil MRI and pathology has been limited by freehand cutting of the specimen by pathologist. Herein, we describe a customized specimen mold that is based on data extracted from the MRI and correlate multi-parametric MRI with the resulting registered slices.

This prospective study includes 22 patients (mean age 59.3 years ranging between 52-74 years) with a mean PSA level of 5.76ng/mL (range, 0.49–16ng/mL). MRI of the prostate was performed on a 3T scanner using 16-channel cardiac and endorectal coils. MRI protocol included triplane T2W TSE MRI, diffusion weighted  MRI (DW MRI), MR spectroscopy (MRS), dynamic contrast enhanced MRI (DCE MRI). Following imaging, patients had robotic prostatectomy and prostatectomy specimens were placed in customized 3D molds based on extracted features from their MRI and printed on a 3D printer. MRI images were slice to slice correlated with annotated whole mount specimens obtained from the customized mold.

Sensitivity, specificity, and ROC area values in the peripheral zone (PZ) for T2W MRI, DW MRI, MRS, DCE MRI were 0.66, 0.6, 0.26, 0.41 and 0.93, 0.93, 0.99, 0.99 and 0.79, 0.76, 0.62, 0.7, respectively. Sensitivity, specificity and ROC area values in the central gland (CG) for T2W MRI, DW MRI, MRS, DCE MRI were 0.41, 0.56, 0.23, 0.47 and 1.0, 0.97, 0.99, 0.99 and 0.7, 0.765, 0.61, 0.73, respectively. Overall, sensitivity, specificity and ROC area values for multi-parametric MRI in PZ and CG were 0.76, 0.89, 0.82 and 0.56, 0.97, 0.76, respectively. Sensitivity, specificity and ROC area values were found to be higher in larger lesions (>5mm in greatest diameter).

Multi-parametric MRI of prostate at 3T enables accurate tumor detection in most cases. Among MR sequences, DW MRI and DCE MRI are the two most helpful for tumor detection in the central gland. This patient-specific mold technique improves co-registration and therefore correlation of MRI with prostatectomy specimens.

 Multi-parametric MRI of prostate at 3T enables accurate tumor detection. Patient-specific mold technique improves co-registration and therefore correlation of MRI with prostatectomy specimens.

Turkbey, B, Mani, H, Shah, V, Bernardo, M, Pohida, T, Pang, Y, Daar, D, Mckinney, Y, Merino, M, Pinto, P, Choyke, P, Multiparametric 3 T MR Imaging of Prostate Cancer: Histopathologic Correlation Using Customized MRI-based Specimen Molds.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9010419.html