Young Hoon Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

So Yeon Kim MD, Presenter: Nothing to Disclose

Kyoung Ho Lee MD, Abstract Co-Author: Nothing to Disclose

Hye Seung Lee MD, Abstract Co-Author: Nothing to Disclose

Do Joong Park, Abstract Co-Author: Nothing to Disclose

Hyung-Ho Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

To evaluate the feasibility of CT lymphography using iodized oil for sentinel node mapping in pigs and in patients with early gastric cancer.

The institutional review board approved clinical study and written informed consent was obtained from all patients. Five pigs underwent CT one hour after gastric submucosal injection of 1 mL iodized oil. After CT examination, sentinel node mapping and removal were undertaken with gastric submucosal injection of 1 mL methylene blue. The removed lymph nodes were examined with radiographic and histopathologic examination. Ten patients with early gastric cancer also underwent CT lymphography with peritumoral submucosal injection of 1 mL iodized oil, followed by sentinel basin extirpation with CT guidance and routine nodal dissection. The removed sentinel basins were examined with radiographic examination. The histopathologic examination was performed for dissected nodes, including sentinel nodes.

In each of five pigs, CT showed one perigastric node with iodized oil retention. After removal of methylene blue stained node, all blue stained nodes were confirmed to have iodized oil retention at both of radiographic and pathologic examinations. In all ten patients, CT one hour after peritumoral injection of iodized oil successfully demonstrated sentinel basin with nodes having iodized oil retention. On CT examination, a total of 20 nodes with iodized oil retention were found. After basin extirpation, 24 and 37 nodes were detected on radiographic and histopathologic examinations, respectively. On histopathologic examination, one patient showed micrometastasis at two sentinel nodes and one patient demonstrated isolated tumor cells at one sentinel node. No patient had metastasis in non-sentinel nodes.

The CT lymphography using iodized oil is a feasible method for sentinel node mapping in patient with early gastric cancer.

CT lymphography using iodized oil is a feasible method for sentinel node mapping in patient with early gastric cancer.

Kim, Y, Kim, S, Lee, K, Lee, H, Park, D, Kim, H, Feasibility of CT Lymphography Using Iodized Oil for Sentinel Node Mapping in Early Gastric Cancer: Animal and Preliminary Clinical Study.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9010313.html