Quantitative Assessment of Liver Tumor Microcirculation: Perfusion Parameters Derived from Contrast-enhanced Ultrasonography Correlate with Perfusion CT

VG21-07

Quantitative Assessment of Liver Tumor Microcirculation: Perfusion Parameters Derived from Contrast-enhanced Ultrasonography Correlate with Perfusion CT

Scientific Formal (Paper) Presentations

Presented on November 29, 2010
Presented as part of VG21: Ultrasound/Gastrointestinal Series: Contrast-enhanced US—Where Are We in 2010?

Thibaud Lefort, Presenter: Nothing to Disclose

Frank Pilleul MD, Abstract Co-Author: Nothing to Disclose

Sébastien Mulé, Abstract Co-Author: Nothing to Disclose

Catherine Lombard Bohas, Abstract Co-Author: Nothing to Disclose

Thomas Walter, Abstract Co-Author: Nothing to Disclose

Aymeric Guibal, Abstract Co-Author: Nothing to Disclose

To use contrast-enhanced ultrasonography (CEUS) for quantification of relative perfusion parameters in liver malignant tumors and to correlate CEUS-derived parameters with perfusion computed tomography (CT) parameters.

Retrospective study including 16 patients with malignant liver lesions, primitive (hepatocellular carcinoma n=2, cholangiocarcinoma n=1) or metastatic (neuroendocrine tumors n=11, colorectal carcinoma n=1, ovarian carcinoma n=1). Each patient underwent CEUS with dynamic study after ultrasound-induced destruction of microbubbles at steady-state in the imaged plane. Relative perfusion parameters in liver tumors were quantified from the destruction-replenishment curves. CEUS-derived parameters, relative Blood Flow (rBF) and relative Blood Volume (rBV), were compared with perfusion CT-derived parameters quantified using a deconvolution method. Statistical analysis used Spearman correlation coefficient.

Significant correlation was observed between CEUS and perfusion CT for rBF (R=0.63, p < 0.01) and rBV (R=0.61, p < 0.02). CEUS-derived rBF (median=4.9, range=1.1 - 9.6) showed perfusion elevation in all tumors compared to reference liver parenchyma.

CEUS-derived parameters are correlated with perfusion CT parameters and provide a non-invasive quantitative measure of liver tumor angiogenesis.

CEUS-derived biomarkers of liver tumor vascularity could be used for non-invasive monitoring of angiogenic inhibitor treatments.

Lefort, T, Pilleul, F, Mulé, S, Bohas, C, Walter, T, Guibal, A, Quantitative Assessment of Liver Tumor Microcirculation: Perfusion Parameters Derived from Contrast-enhanced Ultrasonography Correlate with Perfusion CT. Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9009279.html