Jorge Andres Delgado MD, Abstract Co-Author: Nothing to Disclose

Simon Rascovsky MD, Abstract Co-Author: Nothing to Disclose

Pedro Abad MD, Abstract Co-Author: Nothing to Disclose

Rafael Lince MD, Abstract Co-Author: Nothing to Disclose

Luis Horacio Diaz MD, Abstract Co-Author: Nothing to Disclose

Sergio Andres Uribe PhD, MS, Presenter: Nothing to Disclose

The purpose of this study is to assess ventricular volumes using three dimensional (3D) whole heart MRI data sets acquired during end-systolic (ES) and end-diastolic (ED) phases in one free- breathing scan for pediatric patients undergoing cardiac MRI.

A prospective study was performed in 12 pediatric patients (5 males, mean age 8.4y). A routine clinical Cardiac MR (CMR) protocol was performed on a Philips Achieva MR Scanner using a Flex M coil and a new pediatric coil (composed of 8 channels, with a 4x2 configuration). The CMR protocol included a 3D b-SSFP dual cardiac phase sequence (Uribe et al, Radiology 2008) and multiples short axis (MSA) data covering both ventricles. ED, ES and Stroke volumes were calculated by two independent observers from these data sets. The analysis of MSA and the 3D data sets was performed using a semi-automatic region growing threshold segmentation with open source OSIRIX software (http://osirix-viewer.com). Statistical Bland Altman analyses and correlation coefficient analyses were performed to assess agreement between the measurements and inter observer reproducibility.

No statistically significant differences were observed between the means of the MSA and Dual 3D techniques for LV-EDV (p = 0,803), LV-ESV (p = 0,219), RV-EDV (p = 0,956) y RV-ESV (p = 0,741). The Bland-Altman analysis for LV, RV y SV comparing Dual 3D vs. MSA showed good strength of agreement (CCI > 0.9) The intra- and inter-observer analysis found less variability present with the 3D method as opposed to the M2D

We have validated a 3D cardiac acquisition scheme that allows precise volume quantification in a single free breathing scan in the pediatric population. Cardiac Volumes obtained from the 3D dual phase technique are in excellent agreement with the traditional MSA approach, and with superior reproducibility. Severely ill pediatric patients may benefit from the proposed method, since it provides cardiac function and morphological information at two different cardiac phases in a single free breathing scan.

The methodology presented here allows for accurate volumetric cardiac quantification and morphological information at two cardiac phases in single free breathing MR scan in a pediatric population.

Delgado, J, Rascovsky, S, Abad, P, Lince, R, Diaz, L, Uribe, S, Volumetric Cardiac Quantification Using Three Dimensional Dual Phase Whole Heart MRI in the Pediatric Population.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9009005.html