Ami Ushakant Desai MBBS, MRCP, Presenter: Nothing to Disclose

Neshe Sriskandan MRCP, Abstract Co-Author: Nothing to Disclose

Ata Siddiqui, Abstract Co-Author: Nothing to Disclose

To discuss the structure and function of the globus pallidus and to present the spectrum of disease that may be seen with predominant bilateral pallidal lesions in children and adults.

Globus pallidus structure & function. Differential diagnoses & illustrative MRI findings of bilateral pallidal lesions: 1. Hypoxic/ischemic injury 2. Mitochondrial disorders & inborn errors of metabolism (e.g. methylmalonic aciduria) 3. Neurodegenerative conditions (e.g. Pantothenate kinase-associated neurodegeneration) 4. Toxins (e.g. carbon monoxide) 5. Bilirubin encephalopathy 6. NF 1 7. Manganese deposition 8. Normal variants – perivascular spaces, age-related mineralisation.

The globus pallidus is a major constituent of the basal ganglia. We discuss its structure, function & present the range of pathologies which result in bilateral pallidal abnormalities, some of which are relatively unique to the pallidum. Recent advances in MRI have led to better assessment of individual components of the basal ganglia & better visualization of the globus pallidus. We also discuss other neuroimaging findings which help in narrowing the differential diagnosis of pallidal lesions.

Desai, A, Sriskandan, N, Siddiqui, A, Bilateral Lesions of the Globus Pallidus: Differential Diagnosis and Magnetic Resonance Imaging Findings.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9008663.html