Kristina Elizabeth Hoque PhD, Presenter: Nothing to Disclose

Alexander Lerner MD, Abstract Co-Author: Nothing to Disclose

David A. Stempel MD, MBA, Abstract Co-Author: Nothing to Disclose

Mark S. Shiroishi MD, Abstract Co-Author: Nothing to Disclose

John L. Go MD, Abstract Co-Author: Nothing to Disclose

Orest Bohdan Boyko MD, PhD, Abstract Co-Author: Consultant, Bracco Group Consultant, Patient Comfort Systems, Inc

Paul E. Kim MD, Abstract Co-Author: Nothing to Disclose

Monique Annette Mogensen MD, Abstract Co-Author: Research Consultant, Oraya Therapeutics, Inc

Eu-Meng Law MBBS, Abstract Co-Author: Nothing to Disclose

1. Review anatomy, function and pathways of the hippocampus and the Limbic system with correlation to conventional MRI, fMRI and DTI. 2. Review differential diagnosis of unilateral and bilateral hippocampal lesions and pathophysiology. 3. Present MRI examples and discuss important features correlated with clinical presentation.

Limbic system anatomy and function •Limbic Lobe, Associated nuclei, Fornix and circuit of Papez •Vascular supply Evaluation of Limbic system pathology Bilateral hippocampal atrophy: •Alzheimer disease, Multiple sclerosis •Chronic infarcts and ischemia Hippocampal signal abnormality: •Mesial temposral sclerosis, Glial neoplasm •Herpes encephalits, Limbic encephilitis •Acute infarct in anterior choroidal artery Mammilary bodies hyperintensity: •Wernicke encephalopathy  

Knowledge of the limbic system anatomy is instrumental in recognizing and understanding the pathology involving the hippocampus and its clinical manifestations. Advanced MR imaging techniques and PET can assist in evaluation of the limbic system. The hippocampus and the limbic system are affected by a variety of degenerative, infectious, vascular and neoplastic conditions which can be differentiated with careful analysis of MR imaging and correlation with clinical features.  

Hoque, K, Lerner, A, Stempel, D, Shiroishi, M, Go, J, Boyko, O, Kim, P, Mogensen, M, Law, E, Imaging of the Limbic System: Review of Anatomy and MR Imaging Features of Diseases Involving the Hippocampus and the Circuit of Papez.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9006406.html