Jennifer Renae McEvoy MD, Presenter: Nothing to Disclose

Kirkland W. Davis MD, Abstract Co-Author: Research support, Endocare, Inc

Arthur August De Smet MD, Abstract Co-Author: Nothing to Disclose

1. Explain the difference between skeletal dysplasia and dysostosis. 2. Review the prevalence of the common skeletal dysplasias. 3. Describe the clinical features and radiologic appearance of the most prevalent skeletal dysplasias.  

Introduction Skeletal Dysplasia versus Dysostosis Prevalence Clinical Features and Radiographic Findings: - Osteogenesis Imperfecta (OI) - Multiple Epiphyseal Dysplasia (MED) - Spondyloepiphyseal Dysplasia (SED) - Achondroplasia - Pseudoachondroplasia - Metaphyseal Chondrodysplasia (MC) Summary and Major Teaching Points  

1. These six entities comprise 40% of all skeletal dysplasias and have typical radiographic findings. 2. OI, the most prevalent dysplasia, demonstrates wormian bones, biconcave vertebrae, demineralized gracile bones, and multiple fractures. 3. MED with fragmented, flattened epiphyses + characteristic spinal changes = SED. 4. The skull and interpedicular distances are normal in pseudoachondroplasia, 5. Distinctive findings in MC distinguish it from other metaphyseal pathology such as rickets.

McEvoy, J, Davis, K, De Smet, A, How to Make Sense of Funny Looking Bones: Distinguishing the Common Skeletal Dysplasias.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9004257.html