Xiaoping Tang, Presenter: Nothing to Disclose

Xiao Xin Lan MD, Abstract Co-Author: Nothing to Disclose

Jianhua Yin, Abstract Co-Author: Nothing to Disclose

Zhiyong Liu, Abstract Co-Author: Nothing to Disclose

Xi Wei Min, Abstract Co-Author: Nothing to Disclose

Liqin Liu, Abstract Co-Author: Nothing to Disclose

To investigate the ability of T2*-weighted dynamic susceptibility-weighted contrast material-enhanced (DSC) magnetic resonance (MR) perfusion weighted imaging (PWI) to reflect the dynamic changes in brain microcirculation in rabbits after acute carbon monoxide poisoning, and to attempt to predict the possibility of delayed encephalopathy of acute carbon monoxide poisoning (DEACMP).

DSC MR PWI was performed consecutively in 29 rabbits 1 h, 3 d, 5 d, and 7 d before and after poisoning. The poisoned rabbits were divided into the DEACMP group (n=8) and the no-DEACMP group (n=21) according to the symptoms of DEACMP. Function tool software of MR PWI was used to choose the regions of interest (ROIs) in rabbit brain white matter sections that included the hippocampus. The resulting T2*-weighted signal intensity–time curves produced five cerebral hemodynamic MR imaging measurements: cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), and percentage of signal intensity recovery (PSR). Between-group comparisons were performed with t-tests.

CBV, CBF, MTT, TTP and PSR values did not significantly differ (P > 0.05) between the two groups 1 h, 3 d, or 5 d after poisoning, whereas CBV, MTT, TTP and PSR were significantly different 7d after poisoning (P < 0.05). Seventh day perfusion values were predictive of DEACMP. CBV measure showed that the sensitivity, specificity, and accuracy were 100%, 85.71%, and 89.66%, respectively. Based on MTT, the sensitivity, specificity, and accuracy were 25.00%, 100%, 79.31%, respectively. According to TTP measure, the sensitivity, specificity, and accuracy were 12.50%, 100%, and 75.86%, respectively. As PSR measure revealed that the three ratios reached 100%, 95.24%, and 96.55%, respectively. The pathologic findings were consistent with the imaging outcomes.

The seventh day CBV and PSR values are DEACMP-predictive sensitive factors.

This may contribute to early diagnosis, judgment prognosis, and encephalopathy studies, and it may especially provide a good in vivo model.

Tang, X, Lan, X, Yin, J, Liu, Z, Min, X, Liu, L, Seventh Day CBV and PSR Values Can Predict Delayed Encephalopathy Following Acute Carbon Monoxide Poisoning: DSC MR Perfusion-weighted Imaging.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9003991.html