Kai Nassenstein, Presenter: Nothing to Disclose

Holger Eberle, Abstract Co-Author: Nothing to Disclose

Stefan Maderwald, Abstract Co-Author: Nothing to Disclose

Christina Heilmaier MD, Abstract Co-Author: Nothing to Disclose

Oliver Bruder, Abstract Co-Author: Nothing to Disclose

Thomas W. Schlosser MD, Abstract Co-Author: Nothing to Disclose

To evaluate a TGRAPPA (Temporal Parallel Acquisition Technique) accelerated, single breath-hold, multi-slice cine imaging approach for the assessment of global and regional left ventricular (LV) function in clinical routine.

111 consecutive patients were examined on a 1.5 T scanner. Cine imaging was performed i) with single-slice acquisitions in short-axis orientation, whereas each slice was acquired in a separate breath-hold, using a cine SSFP (TR 2.2 ms, TE 1.1 ms, FA 72°, FOV 270 x 203 mm² - 360 x 270 mm² mm depending on the anatomy of the individual patient, matrix 192 x 144, temporal resolution 39.6 ms, slice thickness 8 mm, no interslice gap) sequence and ii) by a TGRAPPA accelerated cine SSFP (TR 2.6 ms, TE 1.1 ms, FA 72°, FOV 270 x 203 mm² - 360 x 270 mm², matrix 192 x 101, temporal resolution 45.2 ms, slice thickness 8 mm, interslice gap 2 mm, acceleration factor 3) sequence, which covered the entire LV in short-axis slices during a single breath-hold. End-diastolic (EDV), end-systolic (ESV), stroke volumes (SV), ejection fraction (EF) and muscle mass (MM), as well as regional wall motion were assessed for both datasets.

Single breath-hold imaging was feasible in 108 patients and required significant shorter acquisition times (28 ± 6 s vs. 335 ± 87 s, p < 0.001). Excellent correlations were observed for all volumetric parameters derived from both datasets (all intraclass correlation coefficients > 0.97). While EDV and ESV showed marginal lower values for single breath-hold imaging (EDV: -1.6 ± 7.9 ml; ESV: -1.8 ± 6.0 ml, p < 0.05), no differences were observed for SV, EF, and MM (all p > 0.05). Regional wall motion analyses revealed wall motion abnormalities in 43 patients in a total of 234 segments when evaluating the single-slice acquisition datasets, and in the same 43 patients in a total of 224 segments (p = 0.07) when evaluating the single breath-hold multi-slice datasets.

TGRAPPA accelerated multi-slice SSPF imaging allows for fast and accurate assessment of regional and global LV function within a single breath-hold.

TGRAPPA accelerated multi-slice imaging enables assessment of LV function in a single breath-hold, and, therefore enables dramatic reduction in image acquisition times.

Nassenstein, K, Eberle, H, Maderwald, S, Heilmaier, C, Bruder, O, Schlosser, T, Time Is Money: Single Breath-Hold Magnetic Resonance Cine Imaging for Fast Assessment of Global and Regional Left Ventricular Function in Clinical Routine.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9003331.html