Daniel Thomas Ginat MD, MS, Presenter: Nothing to Disclose

Rajiv Mangla MD, Abstract Co-Author: Nothing to Disclose

Gabrielle Yeaney, Abstract Co-Author: Nothing to Disclose

Henry Zenyih Wang MD, PhD, Abstract Co-Author: Nothing to Disclose

Atypical and anaplastic meningiomas have a greater likelihood of recurrence than benign meningiomas. The risk for recurrence is often estimated using the Ki-67 labeling index. The purpose of this study was to determine the correlation between Ki-67 and regional cerebral blood volume (rCBV) and between Ki-67 and apparent diffusion coefficient (ADC) in atypical and anaplastic meningiomas. This information may ultimately be useful for surgical planning.

A retrospective review of atypical and anaplastic meningiomas in 52 patients was performed. The minimum ADC, maximum rCBV, and specimen Ki-67 index were measured. Pearson correlation was used to compare these parameters.

There were 23 cases with available ADC maps and 20 cases with available rCBV maps. The average Ki-67 among the cases with ADC maps and rCBV maps was 16.2 (range 5-38%) and 14.5 (range 3-38%), respectively. The mean minimum ADC was 0.91 (standard deviation: 0.26) and the mean maximum rCBV was 23.4 (standard deviation: 10.0). There was a significant positive correlation between maximum rCBV and Ki-67 (Pearson correlation = 0.69; P = 0.00038). However, there was no significant correlation between minimum ADC and Ki-67 (Pearson correlation = -0.051; P = 0.70).

Maximum rCBV correlated significantly with Ki-67 and may be useful for non-invasive assessment of prognosis and management.

MR perfusion may help determine which meningiomas are more likely to recur and can potentially help select candidates for pre-operative embolization and delineate the need for aggressive resection.

Ginat, D, Mangla, R, Yeaney, G, Wang, H, Correlation of Diffusion and Perfusion MRI with Ki-67 in High Grade Meningiomas.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9002553.html