Bing Yu MD, Presenter: Nothing to Disclose

Qiyong Guo MD, Abstract Co-Author: Nothing to Disclose

Na Liu MD, Abstract Co-Author: Nothing to Disclose

Guoguang Fan PhD, Abstract Co-Author: Nothing to Disclose

To assess the memory/caution impairment and explore the differential of projection , communication and association white mater (WM) in children with primary nocturnal enuresis (PNE) by performing diffusion tensor imaging (DTI) scans.

12 right-handed PNE children (M/F=7:5 , average age 10.4 ±1.3 years ) and 12 age-matched, right-handed, healthy controls (M/F=6:6, 10.0 ±1.2 years ) were recruited for the study. First, intelligence tests were performed using Chinese Wechsler Young Children Scales of Intelligence (C-WISC) in PNE children and controls. The full intelligence quotient (FIQ), verbal IQ (VIQ), performance IQ (PIQ) and memory/caution (M/C) factor were measured. After intelligence tests, DTI scans were performed on a 3.0T MR scanner. Quantitative analysis was performed using the regions of interest (ROI) method settled on the WM fiber tracts  of bilateral anterior superior longitudinal fasciculus (ASLF); posterior superior longitudinal fasciculus (PSLF); cingulum bundle (CB); pericallosal frontal (PCF); uncinate fasciculus (UF); anterior limb of internal capsual (AIC); genu of the corpus allosum (GNU); splenium of the corpus callosum (SPN); middle cerebellar penduncle(MCP); superior cerebellar penduncle (SCP); inferior longitudinal fasciculus (ILF). Mean FA values(mFA) of these WM bundles were measured and compared between two groups using student t tests. A two-tailed P value of less than 0.05 indicated a significant difference between groups.

The FIQ, VIQ and PIQ in the PNE group were within the normal range and did not significantly differ from the control group. The M/C factor was statistically lower in the PNE group . PNE children had lower mFA in WM fiber tracts of right PCF ,right AIC and left MCP than that of controls.

Impairment in memory/caution was detected in PNE children, and the impaired density or reduced myelination of WM fiber tracts of right PCF ,right AIC and left MCP might involved in their memory/caution deficits.  

The dysfunction of WM fiber tracts of prefontal-thalamic-cerebellar circuitry might involved in the memory/caution impairment of PNE children.

Yu, B, Guo, Q, Liu, N, Fan, G, Evaluation of Memory/Caution Impairment in Children with Primary Nocturnal Enuresis: Evidence from Diffusion Tensor Imaging.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9002399.html