Shunyu Gao MD, Presenter: Nothing to Disclose

Xiao-Peng Zhang MD, Abstract Co-Author: Nothing to Disclose

Yong Cui MD, Abstract Co-Author: Nothing to Disclose

Ying-Shi Sun MD, Abstract Co-Author: Nothing to Disclose

Lei Tang MD, Abstract Co-Author: Nothing to Disclose

To explore the relationship between significant signs on preoperative enhanced CT and the prognosis in hepatocellular carcinoma (HCC) patients after radical hepatectomy.

87 patients who underwent preoperative enhanced CT and then radical hepatectomy for HCC were retrospectively enrolled for reviewing their clinical characteristics and CT signs. The status of metastasis and/or recurrence and survival after surgery was followed for evaluating of prognosis. Univariate survival analysis was applied by Kaplan-Meier method and Log-rank test. Then multivariate analysis was carried out by the Cox proportional hazard method.

The 1, 3, 5-year cumulative survival rate of the whole patient group was 80.18%, 65.48% and 42.09%, respectively. With univariate analysis, tumor size, location, satellite nodule, vascular invasion and ratios of tumor to liver parenchyma density in arterial phase and portal phase on CT were risk factors for survival (P<0.05). Further multivariable Cox analysis showed that vascular invasion and ratio of tumor to liver parenchyma density in portal phase on CT were independently significant factors for prognosis (P=0.037, 0.007).

Preoperative enhanced CT was of value for survival evaluation in HCC patient after radical hepatectomy. Vascular invasion and a ratio lower than 0.85 of tumor to liver parenchyma density in portal phase on CT may predict a poor prognosis after radical hepatectomy.

It is helpful to plan a systemic treatment program with preoperative prognosis evaluation.

Gao, S, Zhang, X, Cui, Y, Sun, Y, Tang, L, A Clinical Investigation on Preoperational CT Imaging Factors Influencing the Prognosis of Hepatocellular Carcinoma Patients after Radical Hepatectomy.  Radiological Society of North America 2010 Scientific Assembly and Annual Meeting, November 28 - December 3, 2010 ,Chicago IL. http://archive.rsna.org/2010/9001831.html