Noriyuki Fujima MD, Presenter: Nothing to Disclose

Kohsuke Kudo MD, Abstract Co-Author: Nothing to Disclose

Kinya Ishizaka, Abstract Co-Author: Nothing to Disclose

Yuri Zaitsu MD, Abstract Co-Author: Nothing to Disclose

Khin Khin Tha MBBS, PhD, Abstract Co-Author: Nothing to Disclose

Satoshi Terae MD, Abstract Co-Author: Research grant, J-MAC SYSTEM, Inc Research grant, Medical Image Lab Research grant, FUJIFILM Holdings Corporation

Quantitative and noninvasive measurement of blood oxygen saturation has been reported by using susceptibility weighted imaging (SWI). In this study, we performed quantitative measurement of oxygen saturation in the spinal vein by using SWI, under the condition of drug and physiological load to evaluate the change in venous oxygenation.

SWI of the five healthy volunteers were obtained by using 1.5-T unit, after the caffeine intake, and the three kinds of physiological load (breath holding, BH; hyperventilation, HV; and inspiration of highly concentrated oxygen, Oxy). For each volunteer, five slice locations of the phase images of SWI were selected. Oxygen saturation in the anterior spinal vein (ASV) was calculated from the phase value of ASV and the angle between the ASV and static magnetic field (B0). The time-course of oxygen saturation was evaluated on 0, 20, 40, and 60 min after the caffeine intake. Changes in oxygen saturation after the physiological load were also evaluated. One-way, repeated measures analysis of variance (ANOVA) was used for the statistical comparison. Dunnett test was also used for post-hoc test.

Oxygen saturation of the ASV was gradually decreased after the caffeine load. The average values of oxygen saturation were 0.86 (0 min), 0.85 (20 min), 0.84 (40 min), and 0.81 (60 min), respectively. Significant difference was observed between 0 and 60 min. Oxygen saturation of HV (0.82) was significantly lower, and that of BH (0.89) was significantly higher than that of control value (0.86), respectively. There was no significant difference between Oxy (0.85) and control value.

Non-invasive measurement of oxygen saturation in the spinal vein was feasible by using SWI. Changes in the oxygen saturation under the drug and physiological load can be clearly demonstrated. This method can be a useful tool for the clinical evaluations for spinal cord oxygenation.

Non-invasive measurement of oxygen saturation in the spinal vein was feasible by using SWI. This method can be a useful tool for the clinical evaluations for spinal cord oxygenation.

Fujima, N, Kudo, K, Ishizaka, K, Zaitsu, Y, Tha, K, Terae, S, Non-Invasive Measurement of Venous Oxygen Saturation in the Spine by Using SWI: Quantitative Evaluation under the Condition of Drug and Physiological Load.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8015545.html