RSNA 2009 

Abstract Archives of the RSNA, 2009


SSC17-03

Prognostic Assessment of Primary Central Nervous System Lymphoma: Single Institute Experience

Scientific Papers

Presented on November 30, 2009
Presented as part of SSC17: Radiation Oncology and Radiobiology (Lymphoma and Pediatrics)

Participants

Senzo Taguchi MD, Presenter: Nothing to Disclose
Atsushi Nishikawa MD, Abstract Co-Author: Nothing to Disclose
Takashi Ochi MD, Abstract Co-Author: Nothing to Disclose
Takashi Fujii MD, Abstract Co-Author: Nothing to Disclose
Teruhito Mochizuki MD, Abstract Co-Author: Nothing to Disclose

PURPOSE

Primary central nervous system lymphoma (PCNSL) is rare, but its incidence is rapidly increasing. PCNSL is initially radiosensitive, but unfortunately its remission is short-lived, resulted in poor overall survival. The purpose of this study was to investigate the predictor of prognosis in PCNSL.

METHOD AND MATERIALS

From January 1983 to December 2006, 63 patients with PCNSL treated by radiation therapy were included. 36 males and 27 females, age ranged from 10 to 89 years old with a median age of 66 years. Performance status (PS) of patients were as follows; PS0 in 6, PS1 in 15, PS2 in 12, PS3 in 12, and PS4 in18. Histopasological diagnosis were obtained in 34 patients. Others were judged from clinical findings.We retrospectively investigated the relationship of patient prognosis to the following clinical variables: patient age, gender, performance status (PS), total radiation dose, initial response. The survival data were analyzed using the Kaplan-Meyer methods and compared using the log-rank test.

RESULTS

For all 63 patients, the median survival time was 14 months and the survival rates were 38% at 2 years and 19% at 5 years. There were no significant predictor, however, patients with younger age (< 60 years) and better PS (PS = 0 or 1) showed better prognosis.

CONCLUSION

We investigated the prognosis of PCNSL in our institute. Younger age and good PS seemed to be predictors of prognosis in PCNSL.

CLINICAL RELEVANCE/APPLICATION

We investigated the prognosis of PCNSL in our institute. Younger age and good PS seemed to be predictors of prognosis in PCNSL.

Cite This Abstract

Taguchi, S, Nishikawa, A, Ochi, T, Fujii, T, Mochizuki, T, Prognostic Assessment of Primary Central Nervous System Lymphoma: Single Institute Experience.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8015510.html