Marc Regier, Presenter: Nothing to Disclose

Dorothee Schreiter MD, Abstract Co-Author: Nothing to Disclose

Thorsten Derlin, Abstract Co-Author: Nothing to Disclose

Philipp Georg Christian Begemann MD, Abstract Co-Author: Nothing to Disclose

Hendrik Kooijman, Abstract Co-Author: Nothing to Disclose

Eckard Laack, Abstract Co-Author: Nothing to Disclose

Hans Klose MD, Abstract Co-Author: Nothing to Disclose

Gerhard B. Adam MD, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

To evaluate diffusion weighted MR imaging (DWI) with ADC measurement as a new tool for quantitative tumor analysis in nonsmall cell lung cancer (NSCLC) in comparison to standardized uptake values (SUV) as determined by positron emission tomography computed tomography (PET-CT).

Both DWI (TR/TE, 2000/66ms; FOV, 425x298mm; Matrix 256; slice thickness, 8mm; b-values, 0 und 500s/mm²; field strength, 1.5T) and PET-CT were performed in 34 consecutive patients with histologically verified NSCLC disease prior to the surgical resection or initiation of chemotherapy. By placing a Region of Interest (ROI) encovering the entire tumor manifestation the mean (ADCmean), minimum (ADCmin) and maximum ADC (ADCmax) were determined by two independent radiologists. Furthermore, the relative ADCmin (rADCmin = ADCmin/ADCmean) and ADCmax (rADCmax = ADCmax/ADCmean) were assessed. Reading the PET-CT images calculation of the mean (SUVmean) and maximum (SUVmax) tumor metabolism as well as the relative SUVmean (rSUVmean) and SUVmax (rSUVmax) was performed in consensus. The results of DWI and PET-CT were intraindividually compared. For statistical analysis Pearson`s correlation coefficient was assessed.

Comparison of the ADCmin and SUVmax revealed an inverse correlation. Furthermore, the rADCmin and rSUVmax showed a high correlation which was statistically significant (r=0.923; p=0.021). In contrast, there was no correlation neither between maximum ADC values and minimum SUV (r=0.19; p=0.71) nor between mean ADCs and SUVs (r=0.33; p=0.48), regardless of absolute or relative quantitative analysis.

Minimum ADC values correlate with higher tumor metabolism as determined by PET-CT and SUV measurements. As higher standardized uptake values are an established indicator of poor prognosis in primary lung cancer, DWI with ADC measurement might represent a new severity marker in patients suffering from NSCLC.

MRI with determination of the minimum ADC value might be referred to as a powerful alternative technique in the evaluation of tumor metabolism in NSCLC patients.

Regier, M, Schreiter, D, Derlin, T, Begemann, P, Kooijman, H, Laack, E, Klose, H, Adam, G, et al, 0, Diffusion-weighted MRI and FDG-PET in Nonsmall Cell Lung Cancer (NSCLC): Does the Apparent Diffusion Coefficient (ADC) Correlate with the Tracer Uptake (SUV)?.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8015247.html